NCT00154414 |
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Effect of Liraglutide on Blood Glucose Control in Japanese Subjects With Type 2 Diabetes
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NCT00154401 |
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Effect of Liraglutide on Blood Glucose Control in Subjects With Type 2 Diabetes
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NCT00154388 |
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Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases
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NCT00154375 |
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Study of Imatinib Mesylate in Combination With Hydroxyurea Versus Hydroxyurea Alone as an Oral Therapy in Patients With Temozolomide Resistant Progressive Glioblastoma
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NCT00154362 |
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The Efficacy and Safety of Oral Oxcarbazepine 300-1200 mgDay as Adjuvant Therapy in the Treatment of Adolescents With Impulsivity and Aggressive Behavior in Conduct Disorder This Study is Not Being Conducted in the United States
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NCT00154349 |
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Efficacy Study of Imatinib Mesylate to Treat Philadelphia-Positive Acute Lymphocytic Leukemia
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NCT00154336 |
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A Study of Imatinib 400 mg Once Daily in Combination With Methotrexate in the Treatment of Rheumatoid Arthritis
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NCT00154323 |
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The Efficacy and Safety of Oral Oxcarbazepine 300-1200 mgDay as Adjuvant Therapy in the Treatment of Bipolar Disorder I or II This Study is Not Being Conducted in the United States
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NCT00154310 |
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Efficacy and Safety of Everolimus With Enteric-Coated Mycophenolate Sodium EC-MPS in a Cyclosporine Microemulsion-free Regimen Compared to Standard Therapy in de Novo Renal Transplant Patients
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NCT00154297 |
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Efficacy and Safety of Early Versus Delayed Administration of Everolimus in de Novo Renal Transplant Patients
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NCT00154284 |
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Everolimus in a Cyclosporine Microemulsion-free Regimen Compared to a Low-dose Cyclosporine Microemulsion Regimen in de Novo Kidney Transplant Patients
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NCT00154271 |
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Effects of Blood Pressure Reduction on High Sensitivity C-Reactive Protein hsCRP
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NCT00154258 |
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A Long Term Study of Clozapine in Patients With Treatment-resistant Schizophrenia
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NCT00154245 |
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A One-year Open Label Study to Investigate the Safety and the Effect of Enteric-coated Mycophenolate Sodium EC-MPS in Combination With Cyclosporine Microemulsion in de Novo Kidney Transplant Recipients
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NCT00154232 |
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Study to Evaluate the Combination of Enteric-coated Mycophenolate Sodium EC-MPS Basiliximab and C2-monitored Cyclosporine in de Novo Renal Transplant Recipients at Potential High Risk of Delayed Graft Function DGF
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NCT00154219 |
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Efficacy and Safety Study of Lumiracoxib in Patients With Primary Hip Osteoarthritis
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NCT00154206 |
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Study of Enteric-coated Mycophenolate Sodium EC-MPS With Cyclosporine Microemulsion and Steroids in Pediatric de Novo Renal Transplant Patients
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NCT00154193 |
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Nordic Study in Cardiac and Lung Transplantation Outcome in Relation to Cyclosporine Microemulsion C2 Levels
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NCT00154180 |
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Kronos Early Estrogen Prevention Study KEEPS
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NCT00154167 |
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Safety and Efficacy Study of NV-101 in Dental Patients
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NCT00154154 |
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Hope for the Chronically Suicidal Patient
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NCT00154141 |
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Evaluation of Fibrin Sealant 2 in Vascular Surgical Procedures
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NCT00154128 |
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The Influence of a Stabilization Splint on the Body Posture
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NCT00154115 |
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Levosimendan in High Risk Heart Valve Surgery
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NCT00154102 |
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Cetuximab Combined With Irinotecan in First-line Therapy for Metastatic Colorectal Cancer CRYSTAL
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NCT00154089 |
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A Pilot Study of EM-1421 for the Treatment of Cervical Intraepithelial Neoplasia
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NCT00154076 |
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A Multicenter Comparative Trial of Zonisamide and Topiramate as Initial Monotherapy in Untreated Epilepsies
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NCT00154063 |
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Efficacy and Safety Study of E2007 in Migraine Prophylaxis
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NCT00154050 |
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High Dose Candesartan Versus Quinapril for Restenosis Prophylaxis After Stent Angioplasty
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NCT00154037 |
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Investigation of Vascular Relaxing Effects of Candesartan and Pioglitazone
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NCT00154024 |
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Comparison of Vascular Effects After Therapy With Irbesartan and Atorvastatin
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NCT00154011 |
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Investigation of Vascular Relaxing Effects of the Antidiabetic Rosiglitazone
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NCT00153998 |
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Cetuximab in Neoadjuvant Treatment of Non-Resectable Colorectal Liver Metastases CELIM
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NCT00153985 |
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Allogeneic Stem Cell Transplantation Following Chemotherapy in Patients With Hemoglobinopathies
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NCT00153972 |
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Dopamine Turnover Rate as Surrogate Parameter for Diagnosis of Early Parkinsons Disease
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NCT00153959 |
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Psychiatric Day Hospital Treatment
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NCT00153946 |
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Edaravone and Argatroban Stroke Therapy Study for Acute Ischemic Stroke
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NCT00153933 |
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Bortezomib in Combination With CC-5013 in Patients With RelapsedRefractory Multiple Myeloma
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NCT00153920 |
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Bortezomib Velcade in Patients With Untreated Multiple Myeloma
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NCT00153907 |
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Navelbine and Capecitabine in the Treatment of Metastatic Breast Cancer
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NCT00153894 |
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Effects of Exercise Intervention on Insulin Levels in Breast Cancer Survivors
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NCT00153881 |
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Docetaxel and Carboplatin Followed by Oral Capecitabine Docetaxel and Radiation for Esophageal Cancer
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NCT00153868 |
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A Web-based Study of Quality of Life Benefits Associated Aranesp in Anemic Patients With Cancer
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NCT00153855 |
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Structural Brain Abnormalities in Children Born Prematurely New Detection Methods and Clinical-Pathological Correlates
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NCT00153842 |
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A Study of Paclitaxel and Carboplatin in Combination With Bexarotene Oral Capsules in Patients With Advanced Lung Cancer
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NCT00153829 |
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Chronic Illness Care Management CICM Study In Primary Care
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NCT00153816 |
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Vitamin DCalcium Polyp Prevention Study
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NCT00153803 |
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Erlotinib or Placebo Following Chemoradiotherapy ChemoRT in Stage III Non-Small Cell Lung Cancer NSCLC
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NCT00153790 |
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LEAN Project Weight Loss and Appetite Suppression
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NCT00153777 |
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Cellulose Sulfate and HIV Transmission Among Women
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NCT00153764 |
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Effectiveness of a Vitamin Mineral Supplement
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NCT00153751 |
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The Efficacy of Herbal Medicine in Relieving Symptoms and Change of Quality of Life of Patients With Irritable Bowel Syndrome IBS
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NCT00153738 |
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Phytosterol Supplementation and Cardiovascular Risk
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NCT00153725 |
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Intravenous Pantoloc In Aspirin-Induced Ulcer Bleeding
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NCT00153712 |
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Natural History of Non-steroidal Anti-inflammatory Drug and Non-Helicobacter Pylori in Bleeding Peptic Ulcers
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NCT00153699 |
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Relationship Between Topiramate Use and Ocular Angle Status
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NCT00153686 |
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Capsule Endoscopy or Mesenteric Angiogram in Patients With Overt Gastrointestinal Bleeding GIB of Obscure Origin
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NCT00153673 |
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Effect of Selective COX-2 Inhibition on Ulcer Healing
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NCT00153660 |
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Celecoxib Versus Naproxen for Prevention of Recurrent Ulcer Bleeding in Arthritis Patients
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NCT00153647 |
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A Study to Assess Cap-Assisted Colonoscopy Versus Regular Colonoscopy for the First or Repeated Colonoscopy
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NCT00153634 |
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Standard vs Biofilm Susceptibility Testing in Cystic Fibrosis CF
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NCT00153621 |
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Prevalence of Proteinuria and Chronic Kidney Disease in Pediatric HIV-Infected Patients
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NCT00153608 |
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WT1 Peptid Vaccination in Carcinomas
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NCT00153595 |
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EWO1 in Persistent Allergic Rhinitis Patients
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NCT00153582 |
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WT1 Peptide Vaccination in Acute Myeloid Leukemia AML
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NCT00153569 |
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Multiepitope Peptide Vaccination in Melanoma
|
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NCT00153556 |
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Study to Eliminate Hib Carriage in Rural Alaska Native Villages
|
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NCT00153543 |
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Immunogenicity and Reactogenicity of Pneumococcal Polysaccharide and Conjugate Vaccines in Native Elders
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NCT00153530 |
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Whole Brain Irradiation in Primary Central Nervous System CNS Lymphoma PCNSL
|
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NCT00153517 |
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Maternal Effects of Bacterial Vaginosis BV Treatment in Pregnancy
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NCT00153504 |
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Housing and Health Study
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NCT00153491 |
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Adherence to Lumefantrine-Artemether
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NCT00153478 |
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Project CHOICES Efficacy Study
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NCT00153465 |
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University of Oklahoma Parenting Program Attrition
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NCT00153452 |
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Workplace Productivity of Persons Who Use Controlling Behavior With Intimate Partners
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NCT00153439 |
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Purdue University Parenting Program Attrition
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NCT00153426 |
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West Virginia WISEWOMAN Project
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NCT00153413 |
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West Virginia WISEWOMAN Pilot Study to Test a Brief Nutrition Intervention
|
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NCT00153400 |
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The California WISEWOMAN ProjectCardiovascularCVD Health for Hispanic Women
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NCT00153387 |
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Illinois WISEWOMAN Project
|
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NCT00153374 |
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Iowa WISEWOMAN Project
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NCT00153361 |
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Project MIX Behavioral Intervention to Reduce Risk Among Substance-Using MSM
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NCT00153348 |
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South Central Foundation - WISEWOMAN Project
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NCT00153335 |
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Computerized Risk Assessment in an Employee Population
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NCT00153322 |
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Shape Up Somerville Eat Smart Play Hard
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NCT00153309 |
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Program Evaluation of People With Arthritis Can Exercise
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NCT00153296 |
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Study of Efficacy of Carbamazepine in Therapy of Patients With Moderate Persistent and Severe Bronchial Asthma
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NCT00153283 |
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Study of Efficacy of Gabapentin in Therapy of Bronchial Asthma
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NCT00153270 |
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Study of Efficacy of Sodium Valproate in Therapy of Bronchial Asthma
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NCT00153257 |
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Comparative Study of Mesh Versus No Mesh in Prolapse Surgery
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NCT00153244 |
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Study of Efficacy of Lamotrigine in Therapy of Bronchial Asthma
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NCT00153231 |
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Posterior IVS Versus Sacrospinous Suspension in Vaginal Vault Prolapse Repair
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NCT00153218 |
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An Observational Study of Current Practice Pattern on the Treatment of Women With Metastatic Breast Cancer Whose Tumors Overexpress Her2neu
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NCT00153205 |
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Serious Medication Errors in Pediatrics Evaluation of Prevention Strategies
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NCT00153192 |
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Study to Evaluate the Efficacy of Dronabinol Marinol as Add-On Therapy for Patients on Opioids for Chronic Pain
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NCT00153179 |
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Free Fatty Acids and Vascular Function in Subjects With Diabetes
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NCT00153166 |
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ARREST PAD Peripheral Arterial Disease
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NCT00153153 |
|
Extended Use of Polyethyleneglycol3350 Laxative in Constipated Patients
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NCT00153140 |
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Polyethyleneglycol3350 vs Tegaserod in Treatment of Patients With Chronic Constipation
|
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NCT00153127 |
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Comparison of PolyethyleneGlycol and Placebo for Relief of Constipation From Constipating Medications
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NCT00153114 |
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PolyethyleneGlycol3350 Laxative vs Placebo in Constipated Children
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NCT00153101 |
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Effectiveness and Safety of Ramipril Alone Compared With Telmisartan Alone and in Combination With Ramipril in Patients at High Risk for Cardiovascular Events Patients Intolerant to Ramipril Were Entered in TRANSCEND Telmisartan Compared to Placebo
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NCT00153088 |
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INNOVATION Study - Telmisartan Micardis in Incipient Diabetic Nephropathy
|
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NCT00153075 |
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Flow Rate Effect Respimat Inhaler Versus a Metered Dose Inhaler Using Berodual in Patients With Chronic Obstructive Pulmonary Disease COPD
|
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NCT00153062 |
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PRoFESS - Prevention Regimen For Effectively Avoiding Second Strokes
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NCT00153049 |
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3 x 3 Factorial Trial of Telmisartan and Hydrochlorothiazide in Patients With Essential Hypertension
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NCT00153036 |
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Rt-PA in the Treatment of Acute Ischemic Stroke
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NCT00153023 |
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1 Year Trial Telmisartan 80 mg Versus Valsartan 160 mg in Hypertensive Type 2 Diabetic Patients With Overt Nephropathy
|
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NCT00153010 |
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An Evaluation of Three Doses of NS 2330 in Patients With Mild to Moderate Dementia of the Alzheimers Type
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NCT00152997 |
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Pramipexole BI-Sifrol Orally Once Daily for 6 Weeks in Patients With Primary Restless Legs Syndrome
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NCT00152984 |
|
Efficacy and Safety of Tiotropium in Patients With COPD and Concomitant Diagnosis of Asthma
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NCT00152971 |
|
Dabigatran Etexilate vs Enoxaparin in Prevention of Venous Thromboembolism VTE Post Total Knee Replacement
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NCT00152958 |
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A Study in Patients Suffering From Idiopathic Restless Legs Syndrome Who Responded to a Preceding 6-month Treatment With Open-label Pramipexole Including Titration 0125 025 05 075 mg Orally qn
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NCT00152945 |
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Determining the Responsiveness of Intestinal Lipoprotein Production to an Elevation of Plasma Free Fatty Acids
|
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NCT00152932 |
|
Ocular Blood Flow in Early Glaucoma Patients Before and After Treatment With Dorzolamide
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NCT00152919 |
|
Mobicox Study of Meloxicam to Reduce Prostate Swelling in Permanent Seed Prostate Brachytherapy
|
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NCT00152906 |
|
Stereotactic Radiotherapy SRT Liver COLD 1
|
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NCT00152893 |
|
To Determine if Chromium Nicotinate Supplementation Will Improve Insulin Resistance in HIV Patients With Metabolic Abnormalities
|
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NCT00152880 |
|
Apoptosis and Hepatitis B The Role of Apoptosis in Patients Who Are HBeAg Negative
|
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NCT00152867 |
|
Dexamethasone Study Impact on Quality of Life of Continuing Dexamethasone Following Emetogenic Chemotherapy
|
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NCT00152854 |
|
Acetaminophen for Cancer Pain
|
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NCT00152841 |
|
Effect of Iron and Vitamin E Supplementation on Disease Activity in Patients With Either Crohns Disease or Ulcerative Colitis
|
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NCT00152828 |
|
Celebrex - Cervix Celecoxib in the Treatment of Patients With Locally Advanced Carcinoma of the Cervix
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NCT00152815 |
|
Non-alcoholic Fatty Liver Disease NAFLD in HIV The Role of Nutritional Interventions
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NCT00152802 |
|
Pneumonia Vaccine in Liver Transplant Recipients a Booster Strategy Using a Conjugate Vaccine
|
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NCT00152789 |
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Normal Prostate Oxygenation of the Prostate Gland in Men Undergoing Prostate Biopsy
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NCT00152776 |
|
Treating Climacteric Symptoms With a Complex Homeopathic Remedy
|
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NCT00152763 |
|
Psychological Support for Patients With an Implantable Cardioverter Defibrillator
|
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NCT00152750 |
|
Study of Clonidine on Sleep Architecture in Children With Tourettes Syndrome TS and Comorbid ADHD
|
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NCT00152737 |
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Objective Evaluation of Proximal Ischemia
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NCT00152724 |
|
Mechanisms of Human Cutaneous Microcirculation in Healthy Volunteers
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NCT00152711 |
|
Impact of nCPAP Treatment on Liver Function in Patients With Sleep Apnea Syndrome and Nonalcoholic Steatohepatitis
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NCT00152698 |
|
Effect of Irbesartan on Endothelial Function of the Retinal Vasculature in Patients With Hypercholesterolemia
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NCT00152685 |
|
High Dose Hyperoncotic Serum Albumin for the Treatment of the Acute Phase of Severe Head Injury
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NCT00152672 |
|
Treatment of Sleep Apnea Syndrome With nCPAP Versus Oral Appliance
|
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NCT00152659 |
|
Developing Criteria for Cortical Resections
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NCT00152646 |
|
Platelets Induced Vasodilation in Vitro and in Vivo Study
|
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NCT00152633 |
|
Effect of Losartan on Retinal Endothelial Function in Patients With Essential Hypertension
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NCT00152620 |
|
Dexamethasone Versus Methylprednisolone for the Treatment of Active Inflammatory Bowel Disease
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NCT00152607 |
|
Orthotopic Liver Transplantation Using a Living Donor
|
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NCT00152594 |
|
Voriconazole or Placebo in the Prophylaxis of Lung Infiltrates in Patients Undergoing Induction Chemotherapy for Acute Myelogenous Leukemia
|
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NCT00152581 |
|
Analysis of the Duration of Combination Therapy That is Necessary for HCV Genotype 1 Eradication
|
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NCT00152568 |
|
The Effectiveness of Car Seat Checks at Routine Pediatric Visits
|
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NCT00152555 |
|
Physical Therapy for Systemic Lupus Erythematosus SLE
|
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NCT00152542 |
|
Follow-up at School-age of Children Who Participated in the Efficacy Study of Nitric Oxide for Premature Infants
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NCT00152529 |
|
CATCH-ITCompetent Adulthood Transition With Cognitive Humanistic and Interpersonal Teaching
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NCT00152516 |
|
Long-Term Follow-Up Study Of the Safety And Efficacy Of Levetiracetam In Children With Partial Onset Seizures
|
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NCT00152503 |
|
Study With Subjects 18-65 Years Old With Partial Onset Seizures Who Are Currently Taking Levetiracetam
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NCT00152490 |
|
A Study to Test the Effect of CDP870 in the Treatment of Crohns Disease Over 26 Weeks Comparing CDP870 to a Dummy Drug Placebo
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NCT00152477 |
|
A Study of PaclitaxelCarboplatin With or Without CDP791 in Patients With Lung Cancer
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NCT00152464 |
|
Prevention of Asthma With Levocetirizine 18 Month Treatment in Infants 12 - 24 Months Suffering From Eczema Atopic Dermatitis and Sensitized to Grass Pollen andor House Dust Mite HDM
|
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NCT00152451 |
|
Study With Seletracetam Ucb 44212 in Adult Subjects 18 to 65 Years With Partial Onset Seizures
|
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NCT00152438 |
|
Vasomotor Symptoms VMS Progesterone Study Vasomotor Symptoms and Endothelial Function - Trial of Oral Micronized Progesterone
|
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|
NCT00152425 |
|
Study to Test the Effect of CDP870 in the Treatment of Crohns Disease Over 26 Weeks Comparing CDP870 to a Dummy Drug Placebo Following 3 Doses of Active Drug CDP870
|
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NCT00152412 |
|
Open Study to Evaluate the Safety of Levocetirizine in Young Children 2 - 6 Years Suffering From Allergic Rhinitis
|
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NCT00152399 |
|
Study to Assess the Efficacy and Safety of Somatostatin in the Treatment of Acute Severe Upper Gastrointestinal Bleeding
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|
NCT00152386 |
|
A Placebo Controlled Study to Assess Efficacy and Safety of Certolizumab Pegol in the Treatment of Rheumatoid Arthritis
|
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|
NCT00152373 |
|
Double-blind Placebo-controlled Study of Levetiracetam in Adults With POS
|
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|
NCT00152360 |
|
The Effect of Xenical on Weight and Risk Factors
|
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NCT00152347 |
|
A Double-Blind Randomized Control Trial Comparing Botulinum Toxin Type A Botox and Placebo in the Treatment of Idiopathic Clubfoot
|
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NCT00152334 |
|
Efficacy of Botox in Patients With Idiopathic Clubfoot
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NCT00152321 |
|
Strategies Targeting Osteoporosis to Prevent Recurrent Fractures
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|
NCT00152308 |
|
Non-Polymer-Based Rapamycin-Eluting Stents to Prevent Restenosis
|
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NCT00152295 |
|
A Long-Term Study to Evaluate the Safety of Asoprisnil and Estrogen Administration to Postmenopausal Women
|
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NCT00152282 |
|
A Study to Evaluate the Safety and Effectiveness of Asoprisnil and Estrogen Administration to Postmenopausal Women
|
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|
NCT00152269 |
|
Treatment of Uterine Fibroids With AsoprisnilJ867
|
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NCT00152256 |
|
A Study to Evaluate of the Safety and Effectiveness of Asoprisnil in Treating Women With Uterine Fibroids
|
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|
NCT00152243 |
|
A Randomized Controlled Study of Postoperative Adjuvant Chemotherapy of Uracil- Tegafur UFT Compared With Surgery Alone NSAS-GC
|
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NCT00152230 |
|
A Randomized Controlled Study of Postoperative Adjuvant Chemotherapy of Uracil- Tegafur UFT Compared With Surgery Alone NSAS-CC
|
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NCT00152217 |
|
Adjuvant Chemotherapy Trial of TS-1 for Gastric Cancer ACTS-GC
|
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NCT00152204 |
|
The Community Effectiveness of IPTi in Southern Tanzania
|
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NCT00152191 |
|
A Randomized Controlled Study of Postoperative Adjuvant Therapy of Uracil-tegafur UFT Compared With CyclophosphamideMethotrexate5-fluorouracil CMF in Breast Cancer NSAS-BC
|
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NCT00152178 |
|
The Comparative Trial of UFT TAM With CMF TAM in Adjuvant Therapy for Breast Cancer CUBC
|
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NCT00152165 |
|
Use of Radiostereometric Analysis RSA Following Spinal Fusion Versus the DYNESYS Stabilization System
|
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NCT00152152 |
|
Use of Radiostereometric Analysis Beads RSA to Measure Motion in the Spine Following Lumbar Spinal Surgery
|
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NCT00152139 |
|
Stem Cell Transplantation for Patients With Hematologic Malignancies
|
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NCT00152126 |
|
Chemotherapy With CD133 Select Autologous Hematopoietic Stem Cells for Children With Solid Tumors and Lymphomas
|
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NCT00152113 |
|
Haploidentical Stem Cell Transplant for Patients With Sickle Cell Disease and Prior Stroke or Abnormal Transcranial Ultrasound
|
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NCT00152100 |
|
Transplantation of Hematopoietic Cells in Children With Severe Combined Immunodeficiency Syndrome
|
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NCT00152087 |
|
A Non-Randomized Study of Internal Radiation Therapy to the Liver in Patients With Primary Liver Cancer for Whom Surgery is Not Possible
|
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NCT00152074 |
|
Salt Reduction on Blood Pressure and Cardiovascular Organ Damage
|
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NCT00152061 |
|
The Switch Study The Role of LamivudineEmtricitabine 3TCFTC in Antiretroviral Regimens
|
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NCT00152048 |
|
Evaluation of Eflornithine on Facial and Forearm Skin
|
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NCT00152035 |
|
Safety of SPD465 in Treating Adults With ADHD
|
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NCT00152022 |
|
Efficacy and Safety of SPD465 in Adults With Moderately Symptomatic ADHD
|
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|
NCT00152009 |
|
Safety and Efficacy of SPD503 in Treating Attention-DeficitHyperactivity Disorder ADHD in Children Aged 6-17
|
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|
NCT00151996 |
|
Safety and Tolerability of SPD503 and Psychostimulants in Children and Adolescents Aged 6-17 With Attention-DeficitHyperactivity Disorder ADHD
|
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NCT00151983 |
|
Safety Tolerability of MTS in Children Aged 6-12 Diagnosed With ADHD Previously Treated With Extended-Release Methylphenidate Therapy
|
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NCT00151970 |
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Efficacy Safety and Tolerability of SPD485 in Children Aged 6-12 Diagnosed With ADHD
|
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NCT00151957 |
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Safety and Tolerability of SPD485 in Children Aged 6-12 Diagnosed With ADHD and Previously Participated in MTS Trials
|
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NCT00151944 |
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Safety and Tolerability of SPD476 in Maintaining Remission in Patients With Ulcerative Colitis
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NCT00151931 |
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Efficacy and Tolerability of Treatment With Lanthanum Carbonate in Patients With End Stage Renal Disease Receiving Dialysis
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NCT00151918 |
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Efficacy and Safety of Lanthanum Carbonate and Sevelamer Hydrochloride in Patients Receiving Haemodialysis for End Stage Renal Disease
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NCT00151905 |
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The Use of an Inhaled Salt Solution to Treat Viral Lung Infections in Infants
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NCT00151892 |
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Efficacy and Safety of SPD476 in Maintaining Remission in Patients With Ulcerative Colitis
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NCT00151879 |
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Safety and Tolerability of Intravenous SPM 927 as Replacement for Oral SPM 927 in Subjects With Partial Seizures
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NCT00151866 |
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Efficacy of Transfusions With Platelets Stored in Platelet Additive Solution II Versus Plasma
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NCT00151853 |
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Study Use of PPSB-SD and VP-VI in Patients With Anticoagulant Therapy and Undergoing Acute CPB Surgery
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NCT00151840 |
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Efficacy and Safety of IVIG-L in ITP Patients
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NCT00151827 |
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Olmesartan Medoxomil in Hypertension and Renal Impairment
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