Bio Spec

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Overview

Bio Spec Overview

Ignite Creation Date: 2025-12-25 @ 12:27 AM
Last Modification Date: 2025-12-25 @ 12:27 AM
Retention: SAMPLES_WITH_DNA
Description: 825 participants who underwent CPSS1 screening have already had a Genome Wide Association Scan (GWAS) and APOE genotyping. A DNA sample for GWAS and APOE genotyping will be collected during the CPLS Study Entry Visit from all potential participants and GWAS will be performed in all cases of missing genetic data. The aim will be to evaluate the role of APOE status individually and of the polygenic risk score (PRS) in risk assessment of cognitive differing cognitive and ATN biomarker trajectories.

Urine, blood (including for serum and plasma) and saliva samples will be collected and stored to allow for the future investigation of biomarkers associated with AD, through targeted or untargeted (omics) assays. Optional faecal samples will be collected for studies of the gut microbiome and its relationship to AD.
Section: 825 participants who underwent CPSS1 screening have already had a Genome Wide Association Scan (GWAS) and APOE genotyping. A DNA sample for GWAS and APOE genotyping will be collected during the CPLS Study Entry Visit from all potential participants and GWAS will be performed in all cases of missing genetic data. The aim will be to evaluate the role of APOE status individually and of the polygenic risk score (PRS) in risk assessment of cognitive differing cognitive and ATN biomarker trajectories. Urine, blood (including for serum and plasma) and saliva samples will be collected and stored to allow for the future investigation of biomarkers associated with AD, through targeted or untargeted (omics) assays. Optional faecal samples will be collected for studies of the gut microbiome and its relationship to AD.