Description Module
The Description Module contains narrative descriptions of the clinical trial, including a brief summary and detailed description. These descriptions provide important information about the study's purpose, methodology, and key details in language accessible to both researchers and the general public.
Description Module path is as follows:
Study -> Protocol Section -> Description Module
Description Module
Ignite Creation Date:
2025-12-24 @ 2:59 PM
Ignite Modification Date:
2025-12-24 @ 2:59 PM
NCT ID:
NCT04464759
Brief Summary:
This study will evaluate the safety, tolerability and efficacy (objective response rate) of using hydroxychloroquine (HCQ) in combination with nivolumab and ipilimumab or with nivolumab alone in subjects with advanced/metastatic melanoma.
Detailed Description:
There are three parts to this Phase 1/2 study in subjects with advanced melanoma:
Phase 1a will identify the MTD and preliminary safety of combination hydroxychloroquine and nivolumab therapy.
Phase 1b will identify the MTD and preliminary safety of hydroxychloroquine administered in conjunction with nivolumab and ipilimumab therapy
Phase 2 will assess the clinical efficacy of combination hydroxychloroquine and nivolumab therapy.
Study:
NCT04464759
Study Brief:
Protocol Section:
NCT04464759