Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 2:16 PM
Ignite Modification Date:
2025-12-24 @ 2:16 PM
NCT ID:
NCT01967095
Eligibility Criteria:
Inclusion Criteria:
* MSKCC pathologically-proven diagnosis locally advanced Stage III not amenable to definitive, curative treatment or Stage IV or recurrent non-small cell lung cancer
* Documented presence of EGFR mutation confirmed by MSKCC or a local facility.
* No prior treatment with erlotinib, gefitinib, or other EGFR tyrosine kinase inhibitors
* Age ≥ 18 years
* Measurable (RECIST 1.1) indicator lesion not previously irradiated.
* Karnofsky Performance Status ≥ 70%
* Ability to take oral medications
* A negative serum pregnancy test obtained within 4 weeks prior to the start of treatment in all women of child-bearing potential.
* All women of child bearing potential and sexually active men must agree to use adequate methods of birth control throughout the study which includes use of oral contraceptives with an additional barrier methods, double barrier methods, Depo-Provera, permanent sterilization of patient or partner or total abstinence.
Expansion A:
* brain metastases or leptomeningeal not previously treated with radiation or surgery
Exclusion Criteria:
* Inadequate recovery from any toxicity related to prior treatment (to Grade 2 or baseline).
* Inadequate hematologic function defined as ANC \< 1000 cells/mm³, Platelet count \<75,000/mm³ or Hemoglobin \<9.0g/dL.
* Inadequate hepatic function defined by AST/ALT \>3x upper limit of normal (ULN), Total bilirubin\>2x ULN, Alkaline phosphatase \>3x ULN.
* Symptomatic brain metastasis requiring radiation therapy or escalating doses of steroids.
* Patients with clinically stable brain metastases or leptomeningeal disease (previously treated or untreated) are eligible. Patients in expansion cohort A must have at least one untreated CNS lesion
* Women who are breastfeeding or pregnant.
* Any evidence of clinically active interstitial lung disease.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT01967095
Study Brief:
Protocol Section:
NCT01967095