Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 4:18 AM
Ignite Modification Date:
2025-12-25 @ 4:18 AM
NCT ID:
NCT05112120
Eligibility Criteria:
Inclusion Criteria:
* Adults ≥ 18 years \< 75 years.
* Clinical diagnosis of RA
* Selected to start Olumiant by their usual rheumatology clinical team in line with local guidance (previous failure of at least 2 DMARDs and moderate to severe disease active disease)
* Right-handed (to reduce neuroimaging heterogeneity)
Exclusion Criteria:
* Inability to provide written informed consent.
* Severe physical impairment (e.g. blindness, deafness, paraplegia).
* Pregnant or breast feeding.
* Contraindications to MRI (e.g. severe claustrophobia).
* Major confounding neurological disease including Multiple Sclerosis, Stroke, Traumatic Brain Injury, Parkinson's Disease, Alzheimer's Disease
* Previous targeted synthetic (e.g. Oluminant, tofacitinib) DMARD exposure.
* Co-morbid medical conditions that may significantly impair physical functional status
* Medical or psychiatric conditions that in the judgment of study personnel would preclude participation in this study (e.g., malignancy, psychosis, suicidal ideation)
* BMI \> 40 or unable to lie comfortably in MRI
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
74 Years
Study:
NCT05112120
Study Brief:
Protocol Section:
NCT05112120