Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 5:03 AM
Ignite Modification Date:
2025-12-25 @ 5:03 AM
NCT ID:
NCT03399318
Eligibility Criteria:
Inclusion Criteria:
* Evidence of Plasmodium falciparum malaria infection by peripheral blood smear or rapid diagnostic test
* Central nervous system (CNS) symptoms associated with malaria. CEREBRAL MALARIA (CM): Impaired consciousness with a Blantyre Coma Score (BCS)(73) ≤2 in children under 5 years or a Glasgow Coma score (GCS) ≤10 in children ≥5 years OR CNS MALARIA: Complicated seizure(s), meaning prolonged (\>15 minutes), focal or multiple; or impaired consciousness or other evidence of impaired consciousness (confusion, delirium) without frank coma (BCS\>2, GCS =11-14)
Exclusion Criteria:
* Circulatory failure (cold extremities, capillary refill \> 3 seconds, sunken eyes, ↓ skin turgor)
* Vomiting in the past 2 hours
* Serum creatinine (Cr) \> 1.2 mg/dL
* A history of liver disease
* Jaundice or a total bilirubin of \>3.0mg/dL
* A history of gastric ulcers or gastrointestinal bleeding
* A history of thrombocytopenia or other primary hematologic disorder
* Petechiae or other clinical indications of bleeding abnormalities
* A known allergy to ibuprofen, acetaminophen, aspirin or any non-steroidal medication
* Any contraindication for nasogastric tube (NGT) placement and/or delivery of enteral medications
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
2 Years
Maximum Age:
11 Years
Study:
NCT03399318
Study Brief:
Protocol Section:
NCT03399318