Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 3:41 PM
Ignite Modification Date:
2025-12-24 @ 3:41 PM
NCT ID:
NCT05188092
Eligibility Criteria:
Inclusion Criteria:
* Admission to one of the participating ICUs;
* Invasively ventilated for less than 24 hours at randomization;
* Expected to be under invasive ventilation for longer than 24 hours after randomization.
Exclusion Criteria:
* Age below 18 years old;
* Suspected or confirmed pregnancy;
* Participation in other interventional trials with similar endpoints;
* Use of long term home mechanical ventilation;
* Neurological condition that can prolong duration of mechanical ventilation (i.e.Guillain-Barré syndrome, high spinal cord lesion, amyotrophic lateral sclerosis, multiple sclerosis, or myasthenia gravis);
* Conditions in which LUS cannot be performed or correctly interpreted (i.e. chest wall abnormalities, morbid obesity, and pre-existing interstitial lung disease);
* Conditions in which targeting a negative fluid balance is discouraged (i.e. subarachnoid bleeding, severe rhabdomyolysis (CK \> 20.000);
* Previous participation in this RCT;
* Patients transferred from another center and invasively ventilated for longer than 24 hours.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT05188092
Study Brief:
Protocol Section:
NCT05188092