Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 4:02 PM
Ignite Modification Date:
2025-12-24 @ 4:02 PM
NCT ID:
NCT04150666
Eligibility Criteria:
Inclusion Criteria:
* Age 18-75 years
* Able to provide informed consent and willing to complete follow-up visits.
* Estimated glomerular filtration(eGFR) rate over 60 ml/min/1•73 m²
* According to the Guideline of Primary Aldosteronism, unilateral PA has been diagnosed and unilateral adrenalectomy has been completed
* Urine volume can be recorded consciously, and daily drinking water volume is less than 2L/d
Exclusion Criteria:
* Pregnant or breastfeeding
* Diagnosed with other types of chronic kidney diseases, such as IgA nephropathy, lupus nephritis, etc.
* History of malignant tumor
* History of kidney stones in past 5 years
* Kidney transplant within past six months (or on waiting list)
* Less than two years life expectancy
* Serum sodium \<130 mEq/L without suitable explanation or Serum calcium \>2.6 mmol/L without suitable explanation
* Currently taking hydrochlorothiazide \>25 mg/d, indapamide \>1.25 mg/d, furosemide \>40 mg, or metolazone \>2.5 mg/d
* Poor blood pressure control (systolic pressure\>180mmHg or diastolic pressure\> 110mmHg)
* Alcoholics, drug addicts, and people with mental disorders who cannot cooperate
* Patient is under fluid restriction (\<1.5 L a day) for kidney disease, heart failure, or liver disease, AND meets any of the following criteria: i) end stage of the disease (heart left ventricular ejection fraction \<40%, NYHA class 3 or 4, or end stage cirrhosis) , ii) hospitalization secondary to ACS,heart failure, stroke,ascites and/or anasarca ,iii)Severe anemia (Hb\<60g/L)
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
75 Years
Study:
NCT04150666
Study Brief:
Protocol Section:
NCT04150666