Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 4:36 PM
Ignite Modification Date:
2025-12-24 @ 4:36 PM
NCT ID:
NCT00431366
Eligibility Criteria:
* INCLUSION CRITERIA:
* Age 18 years and older.
* Right hand dominant (Edinburgh Handedness Quotient greater than 60).
* Able to provide consent for the protocol.
* Hoehn \& Yahr stages: I - III (de novo PD patients); II - IV (advanced PD patients).
* Never treated with antiparkinsonian medications (de novo PD patients).
* Able to go off of antiparkinsonian medications for a minimum 14 hours (advanced PD patients), i.e. overnight withdrawal until after the experiments are completed here at NIH.
EXCLUSION CRITERIA:
* Patients with any other medical, surgical, neurological or psychiatric conditions except PD.
* Patients with known symptomatic wearing off.
* Pregnant women.
* Concurrent use of tricyclic antidepressants, neuroleptic agents, or any other licit or illicit drugs other than antiparkinsonian agents that could lower the seizure threshold.
* Persons with surgically or traumatically implanted foreign bodies such as a pacemaker, an implanted medication pump, a metal plate in the skull, or metal inside the skull or eyes (other than dental appliances or fillings), intracardiac lines that may pose a physical hazard during magnetic stimulation will also be excluded.
* Patients with history of seizure disorder or epilepsy.
* Subjects without the capacity to give informed consent.
* If participation in the study would, in the opinion of the investigators, cause undue risk or stress for reasons such as excessive fatigue, general frailty, or excessive apprehension.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT00431366
Study Brief:
Protocol Section:
NCT00431366