Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 5:03 PM
Ignite Modification Date:
2025-12-24 @ 5:03 PM
NCT ID:
NCT03816150
Eligibility Criteria:
Inclusion Criteria:
* Sedentary office workers the Medical College of Wisconsin who spend greater than 75% of their (8 hours or longer) work-day sitting at a desk. This includes at least 1 period of 2 hours or longer of uninterrupted sitting time per work day.
* Body mass index of 26.0-44.9
* Willing and able to sign Informed consent
* Permission from the subject's supervisor to participate in the intervention
Exclusion Criteria:
* Known history of atherosclerotic cardiovascular disease, including myocardial infarction, stroke, coronary stent, coronary artery bypass grafting, angina and peripheral vascular disease
* Diabetics on insulin or other diabetic medications (pre-diabetes would be acceptable, defined as a HbgA1c of 5.7 to 6.4%, and not on medications)
* Elevated blood pressure (SBP≥150 mm Hg or DBP ≥90 mm Hg) or on medication for hypertension; or SBP \< 100 mm Hg.
* On cholesterol-lowering medication or LDL-C cholesterol ≥190 mg/dL
* Pregnancy, lactating or planning to get pregnant within the next 6 months
* Current tobacco use within previous 12 months. Tobacco use included cigarettes, cigars, and all forms of smokeless tobacco.
* Current excessive alcohol use (defined as more than 14 drinks/week for women, more than 28 drinks/week for men)
* Current illicit drug use, defined as overuse of prescription medications, or of any illegal mind altering substances.
* Known thyroid disease
* Taking diet pills, or supplements other than those contained in a multi-vitamin
* History of musculoskeletal surgery/injury that would interfere with prolonged periods of standing
* History of use of PDE-5 inhibitors for any reason within the last 5 days of screening visit, and the inability to hold use of PDE-5 inhibitors for 5 days prior to each of the FMD evaluations.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
50 Years
Study:
NCT03816150
Study Brief:
Protocol Section:
NCT03816150