Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 5:18 PM
Ignite Modification Date:
2025-12-24 @ 5:18 PM
NCT ID:
NCT01902550
Eligibility Criteria:
Inclusion Criteria:
* Be a healthy non-smoking male with no clinically relevant abnormalities
* Able to perform upright bicycle ergometer exercise test and be able to achieve greater than or equal to 80 percent of maximum heart rate (HR) determined as (220 beats per minute \[bpm\]-age) during the last 10 seconds of the 3rd minute of exercise test
* Agree to abstain from caffeine (example, coffee, tea, chocolate, or caffeine-containing soft drinks) intake during the inpatient portion of the study
* Participants with body mass index between 18 and 32 kilogram per square meter (kg/m\^2) and body weight greater than or equal to 50 kilogram (Kg) at screening
Exclusion Criteria:
* Contraindication to metoprolol tartrate immediate release (metoprolol IR)
* Resting HR less than 50 bpm and blood pressure less than 110/70 millimeter of mercury (mmHg)
* Physical disability that would preclude safe and adequate exercise test performance
* History of or current clinically significant medical illness that the Investigator considers should exclude the subject or that could interfere with the interpretation of the study results
* Determined to have variant cytochrome P4502D6 (CYP2D6) alleles encoding for altered metabolism
* Have a known or suspected intolerance or hypersensitivity to any biologic medication or known allergies or clinically significant reactions to murine, chimeric, or human peptides or proteins
Healthy Volunteers:
True
Sex:
MALE
Minimum Age:
18 Years
Maximum Age:
45 Years
Study:
NCT01902550
Study Brief:
Protocol Section:
NCT01902550