Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 12:37 PM
Ignite Modification Date:
2025-12-24 @ 12:37 PM
NCT ID:
NCT06544161
Eligibility Criteria:
Inclusion Criteria:
* In- and outpatients with liver cirrhosis of any etiology, diagnosed by either liver histology or compatible biochemical, imaging and clinical parameters, being treated at the department of Visceral Surgery and Medicine at Inselspital Bern, University Hospital Bern, Switzerland.
* Age ≥ 18 years
* Indication for IV albumin infusion according to current EASL guidelines\[11\] and BAVENO VII consensus recommendations\[12\] including large volume paracentesis, spontaneous bacterial peritonitis (SBP), AKI with/without HRS.
* Available transthoracic echocardiography assessing right heart function within maximum 3 months from study inclusion.
Exclusion Criteria:
* Patients admitted to intermediate care unit or intensive care unit at the time of albumin infusion
* Previous IV albumin infusion within the last 5 days
* Contraindication to the PLR test (i.e. increased intracranial pressure)
* Contraindication to albumin infusion (i.e. anaphylactic reactions against albumin)
* History of right heart failure
* Clinical evidence of lung edema, hemodynamic instability/shock
* Anatomic IVC abnormalities, such as IVC stenosis and/or thrombosis
* History of orthotopic liver transplant
* Patients unable to provide informed consent
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT06544161
Study Brief:
Protocol Section:
NCT06544161