Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 6:31 PM
Ignite Modification Date:
2025-12-24 @ 6:31 PM
NCT ID:
NCT02238457
Eligibility Criteria:
Inclusion Criteria:
* Males and females age between 21 and 75 years
* Diagnosis of mild to moderate congestive heart failure
* Coronary angiography identifying coronary artery disease as the likely cause of congestive heart failure
* Left Ventricular (LV) ejection fraction between 20 to 40 percent on echocardiography or RNA
* Sinus rhythm
Exclusion Criteria:
* Insulin-dependent diabetes mellitus
* Hypertension (higher than 140/90 mmHg at rest)
* Use of sympatholytic agents such as clonidine, methyldopa, reserpine
* Significant non-cardiac disease, possibly affecting cardiovascular regulation
* Autonomic neuropathy of any cause
* Leg injuries with nerve damage
* Poor bladder control
* Recent history of alcoholism, drug abuse, significant psychiatric disorders
* Known adverse events to AT1-receptor blockers
* Unlikely to tolerate being off digoxin and off blockers of the RAS for a short period
* Ischemic event within past 3 months
* Serum creatinine higher than 200 mmol/L
* Patients taking digoxin for atrial fibrillation
* Patients who require treatment with aldactone
* Patients with more than mild stable angina while on beta-blockers and/or calcium antagonists
* Patients on coumadin
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
21 Years
Maximum Age:
75 Years
Study:
NCT02238457
Study Brief:
Protocol Section:
NCT02238457