Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 7:38 PM
Ignite Modification Date:
2025-12-24 @ 7:38 PM
NCT ID:
NCT03138603
Eligibility Criteria:
Inclusion Criteria
1. Age \>= 50 years
2. Beta-blocker naïve \[30 days prior to surgery\]
3. Previously diagnosed coronary artery disease (CAD), or
1. History of peripheral vascular disease (PVD), or
2. Chronic kidney disease (CKD) \[eGFR ≤60ml/min\], or
3. History of positive stress test or
4. At high risk for CAD (must meet at least 2 criteria):
i. Age \>= 70 years ii. Hypertension iii. Diabetes requiring oral medication or insulin iv. Current smoker or some days smoker within the past 2 years
4. Major non-cardiac, elective surgery under general anesthesia
Exclusion Criteria
Subjects will not be enrolled if any of the following criteria exist:
1. History of stroke, or transient ischemic attack (TIA)
2. Previously diagnosed carotid disease, i.e., either 70% unilateral or 50% bilateral carotid occlusion.
3. Heart rate \<=55bpm
4. Congestive heart failure with New York Heart Association(NYHA) Functional Classification of III-IV or left ventricular heart failure with ejection fraction ≤50%
5. Severe valvular regurgitation
6. Second or third degree atrioventricular (AV) block without pacemaker
7. Active asthma or chronic obstructive pulmonary disease (COPD) with symptoms or resolving symptoms on day of surgery
8. Anemia \[HB\<=9g/dL\]
9. Allergy to beta-blockade drugs
10. Unwilling or unable to give consent for participation
11. Undergoing any carotid endarterectomy, endovascular, endoscopic, superficial, or ambulatory procedures
12. Pregnancy or lactating women
13. Prisoners
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
50 Years
Study:
NCT03138603
Study Brief:
Protocol Section:
NCT03138603