Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 9:36 PM
Ignite Modification Date:
2025-12-24 @ 9:36 PM
NCT ID:
NCT02365532
Eligibility Criteria:
Inclusion Criteria:
* Must, in the opinion of the investigator, be in good health based upon medical history and physical examination, including vital signs
* Have a calculated body mass index (BMI) from 18 to 30 kg/m\^2, inclusive, at study screening
* Have either a normal 12-lead electrocardiogram (ECG) or one with abnormalities that are considered clinically insignificant and which do not interfere with the ability to interpret the QT interval in the opinion of the investigator in consultation with the medical monitor
Exclusion Criteria:
* History of meningitis or encephalitis, epilepsy, seizures (known or suspected), migraines, tremors, myoclonic jerks, sleep disorder, anxiety, syncope, head injuries, or a family history of seizures
* Have any serious or active medical or psychiatric illness (including depression) which, in the opinion of the investigator, would interfere with treatment, assessment, or compliance with the protocol. This would include renal, cardiac, hematological, hepatic, pulmonary (including chronic asthma), endocrine (including diabetes), central nervous, gastrointestinal (including an ulcer), vascular, metabolic (thyroid disorders, adrenal disease), immunodeficiency disorders, active infection, or malignancy that are clinically significant or requiring treatment.
* Presence or history of cardiovascular disease, including structural heart disease, myocardial infarction (by ECG and/or clinical history), history of ventricular tachycardia or torsade de pointes, heart failure or cardiomyopathy (by clinical history and/or left ventricular ejection fraction \< 40%), presence of cardiac conduction abnormalities, a family history of Long QT or Brugada Syndrome, or unexplained death in an otherwise healthy individual between the ages of 1 and 30 years
* Additional cardiovascular-specific exclusion criteria include findings on screening ECG of:
* QTcF interval \> 430 msec
* PR interval \> 220 msec
* QRS duration \> 110 msec
* Second- or third-degree atrioventricular block
* Complete left or right bundle branch block or incomplete right bundle branch block
* Resting heart rate \< 40 or \> 100 beats per minute (bpm)
* Pathological Q waves (defined as Q wave \> 40 msec)
* Ventricular pre-excitation
* More than 2 ectopic beats
* Syncope, palpitations, or unexplained dizziness
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
40 Years
Study:
NCT02365532
Study Brief:
Protocol Section:
NCT02365532