Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 11:17 PM
Ignite Modification Date:
2025-12-24 @ 11:17 PM
NCT ID:
NCT02067156
Eligibility Criteria:
Inclusion Criteria:
* Written informed consent to participate in this study
* Histological or radiological confirmation of glioblastoma
* Recurrent or progressive GBM following at least one (1), but no more than two (2) prior regimens; one of the prior regimens must have included surgery and/or radiotherapy
* Age \> 18 years
* Karnofsky Performance Status (KPS) ≥ 60%
* Life expectancy \> 2 months
* Adequate hematologic, renal and hepatic function
* Adequate coagulation profile
* Not pregnant, nursing or planning to become pregnant; willing to use contraception
Exclusion Criteria:
* Deteriorating neurological symptoms, or need for increasing doses of corticosteroids or new onset of seizures
* Surgical resection or major surgery within 4 weeks or stereotactic biopsy within 1 week of first G-202 treatment
* Toxicity from prior therapy (excluding alopecia) that has not resolved to ≤ Grade 1 unless otherwise specified
* Investigational or cytotoxic therapy within 28 days or nitrosoureas within 42 days of the first treatment with G-202
* Currently requiring any type of full-dose anti-coagulation treatment, systemic administration of antibiotics or chronic administration of anti-viral agents.
* History or evidence of cardiac risk, including QTc interval on screening ECG \>470 msec, left ventricular ejection fraction (LVEF) \< 50%, clinically significant uncontrolled arrhythmias or arrhythmia requiring treatment with the exceptions of atrial fibrillation and paroxysmal supraventricular tachycardia, history of acute coronary syndromes within 6 months prior to the first dose of study therapy (including myocardial infarction and unstable angina, coronary artery bypass graft, angioplasty, or stenting)
* Uncontrolled cardiac or coronary artery disease
* Uncontrolled hypertension (mean systolic BP ≥ 160 mm Hg and/or mean diastolic BP ≥ 100 mm Hg on 3 determinations 5 minutes apart while on 2 anti-hypertensive agents) or hypertension requiring treatment with more than 2 anti-hypertensive agents
* Severe or uncontrolled medical disease, including uncontrolled diabetes, congestive heart failure, chronic renal disease or chronic pulmonary disease
* Severe GI bleeding within 12 weeks of treatment with G-202
* Known history of HIV, hepatitis B or hepatitis C
* Documentation of keratosis follicularis (also known as Darier or Darier-White disease)
* Requirement for chronic use of strong inhibitors or inducers of cytochrome (CYP3A4) iso-enzymes
* Known hypersensitivity to any study drug component including thapsigargin derivatives, polysorbate 20, or propylene glycol
* Any other condition, including concurrent medical condition, social circumstance or drug dependency, which in the opinion of the investigator could compromise patient safety and/or compliance with study requirements
* Another primary malignancy that has not been in remission for at least 2 years; non-melanoma skin cancer, intraepithelial carcinoma of the cervix, or prostate cancer with a current PSA ≤ 0.1 ng/mL is allowed
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT02067156
Study Brief:
Protocol Section:
NCT02067156