Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 12:22 AM
Ignite Modification Date:
2025-12-25 @ 12:22 AM
NCT ID:
NCT05633758
Eligibility Criteria:
Inclusion Criteria:
* Subject is 18 years of age at time of enrollment.
* Admitted with acute decompensated heart failure based on history, physical exam, and laboratory parameters, must include both:
1. At least 1 symptom of either dyspnea, orthopnea, or edema.
2. At least 1 sign of rales on auscultation, peripheral edema, ascites, or pulmonary vascular congestion on chest radiography.
* Be willing to comply with protocol-specified instructions
* Able to understand and grant informed consent.
Exclusion Criteria:
* Inability to give informed consent.
* Systolic BP \< 90 mmHg
* Creatinine clearance less than 20ml/min or creatinine greater than 2.5mg/dl.
* Serum Sodium less than 128meq/L, potassium levels less than 3.5meq/L
* Known adverse reaction to metolazone
* Inability to take oral medications
* Severe Aortic Stenosis (AVA \< 0.8cm³)
* History of Hypertrophic Obstructive Cardiomyopathy.
* Metastatic Carcinoma
* Severe Chronic Obstructive Pulmonary Disease (COPD), FEV \< 1L
* Severe dyspnea requiring prolonged CPAP or intubation
* Moderate/Severe Dementia
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT05633758
Study Brief:
Protocol Section:
NCT05633758