Ignite Creation Date:
2024-05-05 @ 10:00 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005536
Status:
COMPLETED
Last Update Posted:
2016-05-13
First Post:
2000-05-25
Brief Title:
Genetic Analysis of Human Hypertensive End Stage Renal Disease H-ESRD
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2005-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To identify genes causing hypertensive end-stage renal disease H-ESRD in high risk African-American populations
Detailed Description:
BACKGROUND
Although hypertension is a predisposing factor for end stage renal disease the underlying hypothesis of this study was that in select African-American families genetic factors predisposed them to develop ESRD in the face of hypertension An inherited basis for H-ESRD was supported by familial clustering of H-ESRD among African Americans that could not be explained by socioeconomic status access to medical care and the prevalence of diabetes and hypertension
DESIGN NARRATIVE
DNA samples were collected identified and clinically characterized from African-American sib-pairs and other family members with hypertensive end-stage renal disease This aspect of the study was based on the fact that Dr Freedman the principal investigator had already developed a unique family history of end-stage renal disease database independently funded by the End-Stage Renal Disease Network Six This registry served as a very large and unique collection of African-American end-stage renal disease patients He began with a candidate gene approach for linkage to hypertensive end-stage renal disease in his patient samples using a variety of growth factor genes genes involved in sodium transport and vascular tone as well as human homologues of rodent genes that had or were to be identified in the future as contributing to ESRD in that organism If this initial first pass of candidate genes failed to demonstrate linkage to hypertensive end-stage renal disease a systematic genome-wide scan was to be performed with available simple sequence length polymorphisms SSLP and other polymorphic markers Hypertensive end-stage renal disease is a condition of enormous clinical and economic importance and identification of associated or causative renal-failure genes would form a genetic basis for the detection of high-risk individuals and assist in development of intervention and treatment strategies to prevent this condition
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Although hypertension is a predisposing factor for end stage renal disease the underlying hypothesis of this study was that in select African-American families genetic factors predisposed them to develop ESRD in the face of hypertension An inherited basis for H-ESRD was supported by familial clustering of H-ESRD among African Americans that could not be explained by socioeconomic status access to medical care and the prevalence of diabetes and hypertension
DESIGN NARRATIVE
DNA samples were collected identified and clinically characterized from African-American sib-pairs and other family members with hypertensive end-stage renal disease This aspect of the study was based on the fact that Dr Freedman the principal investigator had already developed a unique family history of end-stage renal disease database independently funded by the End-Stage Renal Disease Network Six This registry served as a very large and unique collection of African-American end-stage renal disease patients He began with a candidate gene approach for linkage to hypertensive end-stage renal disease in his patient samples using a variety of growth factor genes genes involved in sodium transport and vascular tone as well as human homologues of rodent genes that had or were to be identified in the future as contributing to ESRD in that organism If this initial first pass of candidate genes failed to demonstrate linkage to hypertensive end-stage renal disease a systematic genome-wide scan was to be performed with available simple sequence length polymorphisms SSLP and other polymorphic markers Hypertensive end-stage renal disease is a condition of enormous clinical and economic importance and identification of associated or causative renal-failure genes would form a genetic basis for the detection of high-risk individuals and assist in development of intervention and treatment strategies to prevent this condition
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL056266 | NIH | None | httpsreporternihgovquickSearchR01HL056266 |