Ignite Creation Date:
2024-05-05 @ 11:14 PM
Last Modification Date:
2024-10-26 @ 10:30 AM
Study NCT ID:
NCT01280448
Status:
UNKNOWN
Last Update Posted:
2011-01-20
First Post:
2011-01-19
Brief Title:
The Correlation Between Lung Cancer Susceptibility Drug Response and Genetic Polymorphism
Sponsor:
Taipei Medical University WanFang Hospital
Organization:
Taipei Medical University WanFang Hospital
Study Overview
Official Title:
The Correlation Between Lung Cancer Susceptibility Drug Response and Genetic Polymorphism
Status:
UNKNOWN
Status Verified Date:
2011-01
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Lung cancer is the leading cause of cancer deaths in Taiwan The carcinogen in the environment is a key role in the development of lung cancer and one of its main resource is tobacco Activated carcinogens in the organism lead to mutations of crucial oncogenes resulting in tumor development Genes such as Cytochrome P-450 family GST glutathione S-transferase family UGT UDP-Glucuronosyltransferase family ERCC-1excision repair cross-complementing rodent repair deficiencyERCC-4 and ERCC-5are encoding antioxidant enzymes or involving in the DNA repair process and the production of some transcription factors In recent years many studies have shown the correlation between these genes and the susceptibility of lung cancer Each gene has a different role in the tumor development pathway CYP UGT GST NAT2 N-acetyltransferase 2 and NQO1NADPHquinono oxidoreductase 1 involve in the production of antioxidant enzymes The antioxidant enzymes can detoxificate hydrogen peroxide or defense against oxidative stress However the genetic polymorphisms may influence the function of detoxification which cause the increase in the susceptibility of lung cancer P53 and MDM2 genes play important roles in the production of tumor-suppression proteins and the regulation of transcription factors which may regulate the growth and the apoptosis of cell cycle and influence the susceptibility of lug cancer The polymorphisms in ERCC genes may cause the damage in the DNA repair process which might also cause increase in lung cancer susceptibility The overexpression of epidermal growth factor receptor is highly correlated with increasing risk of the non-small cell lung cancers The overexpression may induce the proliferation of cancer cells and the inhibition of the apatosis Therefore in recent years EGFR has been widely studied as the new target of the drugs and the susceptibility of the lung cancer In additionthe genetic polymorphisms in drug metabolism channel proteins like OCT2 organic cation transporter ATP7A ATP7B and ABC ATP-binding cassette transporter may have influence on the metabolism the efficacy and the toxicity of the drugs
Detailed Description:
The current study is a matched case-control study The experimental group is the patients diagnosed as lung cancer at Taipei Medical University- Wanfang Hospital from January 2010 to December 2013 and one healthy patient will be matched to each case as the control group The purpose of the current study is to investigate the association between genetic polymorphisms and lung cancer in the Taiwanese population and to analyze the correlation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None