Ignite Creation Date:
2024-05-05 @ 11:32 AM
Last Modification Date:
2024-10-26 @ 9:09 AM
Study NCT ID:
NCT00078364
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2004-02-23
Brief Title:
Pain Pathways in the Brain
Sponsor:
National Institute of Dental and Craniofacial Research NIDCR
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Imaging Neural Mechanisms Underlying Pain Modulation
Status:
COMPLETED
Status Verified Date:
2005-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will evaluate brain pathways involved in feeling pain and pain relief following administration of pain medication Magnetic resonance imaging MRI will be used to measure brain activity at sites that become more active following oral surgery and then to see if the activity changes after pain medication is administered MRI combines a powerful magnet with an advanced computer system and radio waves to produce detailed pictures of organs and tissues During the scan the subject lies on a table in a narrow cylinder containing a magnetic field He or she can speak with a staff member via an intercom system at all times during the procedure
Healthy dental patients recruited through the NIH Clinical Research Volunteer Program may enroll in this study Participants will undergo the following tests and procedures in two clinic visits
Visit 1 - Sensitivity Testing
Participants are tested for sensitivity to warm and hot temperatures A probe is applied to the skin usually the forearm and heated to temperatures ranging from room temperature to that of a hot cup of coffee Participants rate the temperature using a scale ranging from no pain to the worst pain imaginable and rate the unpleasantness of the heat using a similar scale The probe is applied up to 30 times using random heat intensities Participants are also asked compare the heat intensity to varying levels of sounds and to rate the magnitude of different sensations they have experienced in the past such as the brightness of the sun and the loudness of a jet plane A blood sample of about 2 ounces is also collected at this visit for DNA analysis to look for genes related to pain
Visit 2 - Oral Surgery
Under local anesthetic participants undergo extraction of their lower right wisdom tooth After surgery the patient is moved to the MRI scanner for brain imaging over 1-2 hours while the local anesthetic wears off Patients may request a postoperative pain drug Toradol during the procedure if needed When the scan is complete patients are dismissed from the clinic with additional pain medication flurbiprofen to use at home as directed
Healthy dental patients recruited through the NIH Clinical Research Volunteer Program may enroll in this study Participants will undergo the following tests and procedures in two clinic visits
Visit 1 - Sensitivity Testing
Participants are tested for sensitivity to warm and hot temperatures A probe is applied to the skin usually the forearm and heated to temperatures ranging from room temperature to that of a hot cup of coffee Participants rate the temperature using a scale ranging from no pain to the worst pain imaginable and rate the unpleasantness of the heat using a similar scale The probe is applied up to 30 times using random heat intensities Participants are also asked compare the heat intensity to varying levels of sounds and to rate the magnitude of different sensations they have experienced in the past such as the brightness of the sun and the loudness of a jet plane A blood sample of about 2 ounces is also collected at this visit for DNA analysis to look for genes related to pain
Visit 2 - Oral Surgery
Under local anesthetic participants undergo extraction of their lower right wisdom tooth After surgery the patient is moved to the MRI scanner for brain imaging over 1-2 hours while the local anesthetic wears off Patients may request a postoperative pain drug Toradol during the procedure if needed When the scan is complete patients are dismissed from the clinic with additional pain medication flurbiprofen to use at home as directed
Detailed Description:
Functional neuroimaging provides a powerful tool for understanding how the brain may be involved in the perception of pain It has made it possible to identify areas of the brain that are involved in the perception of experimental pain but very few studies have evaluated the sites in the brain that are activated during clinical pain and the effects of analgesic drugs The proposed study will use the surgical removal of an impacted third molar as a model of acute clinical pain to identify sites that are activated following the offset of local anesthesia and to examine the effects of the NSAID analgesic ketorolac on attenuating sites that are activated as pain is relieved Scans will be performed under non-pain baseline conditions and again immediately following surgery as the local anesthetic wears off clinical pain occurs and following administration of the NSAID ketorolac Differences among subjects in the amount of pain reported and brain activation will be compared to subjects prior ratings of experimental pain and the presence of any genetic polymorphisms that are related to pain perception inflammation known pain pathways or psychological factors related to pain The findings from this research may help to reveal how pain is appreciated in the central nervous system pharmacologically modified by NSAID analgesics and differs among individuals due to genetic factors
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 04-D-0125 | None | None | None |