Ignite Creation Date:
2024-05-05 @ 11:33 AM
Last Modification Date:
2024-10-26 @ 9:09 AM
Study NCT ID:
NCT00071019
Status:
COMPLETED
Last Update Posted:
2017-04-20
First Post:
2003-10-09
Brief Title:
Dietary Fatty Acids PPAR Activated Genes and CHD
Sponsor:
Harvard School of Public Health HSPH
Organization:
Harvard School of Public Health HSPH
Study Overview
Official Title:
Dietary Fatty Acids PPAR Activated Genes and CHD
Status:
COMPLETED
Status Verified Date:
2017-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To examine the relationship between genetic and dietary factors that modify the risk of coronary heart disease CHD
Detailed Description:
BACKGROUND
Coronary heart disease CHD is the major cause of death in most industrialized and developing countries Links between genetic and dietary factors that modify the risk of CHD should give fundamental insight into its causes and improve population-based CHD prevention strategies
DESIGN NARRATIVE
The study will identify genes that modulate the association between dietary fatty acids FAs and myocardial infarction MI The study uses DNA samples obtained during a population-based case-control study in Costa Rica of 2150 subjects who experienced myocardial infarctions and 2150 matched controls Biochemical measurements dietary data and general information are available for this population One unique aspect of the study is that adipose tissue biomarkers of polyunsaturated FAs will be used to evaluate dietary exposure variables Adipose tissue biomarkers ie alpha-linolenic and linoleic acid are very good indicators of intake in this population Furthermore this study showed that increased levels of these biomarkers in adipose tissue are strongly associated with decreased risk of MI whereas an increase in 182 trans FAs increase the risk of MI Gene-diet association studies and a candidate pathway approach will be used to elucidate genetic mechanisms that link risk of MI with exposure to polyunsaturated FAs including cis and trans isomers of linoleic acid n-6 and alpha-linolenic acid n-3 The focus will be on peroxisome proliferator-activated receptor PPAR genes and PPAR-regulated genes that are involved in vascular inflammation Among controls the investigators will examine whether genetic and dietary factors independently affect biochemical markers phenotypes of the proposed genes They will also test whether these phenotypes are more clearly identified when genetic and dietary factors are examined together Because polyunsaturated FAs are important as activators of PPARs and their capacity to regulate gene expression at the level of transcription this metabolic system is a suitable candidate for the study
Coronary heart disease CHD is the major cause of death in most industrialized and developing countries Links between genetic and dietary factors that modify the risk of CHD should give fundamental insight into its causes and improve population-based CHD prevention strategies
DESIGN NARRATIVE
The study will identify genes that modulate the association between dietary fatty acids FAs and myocardial infarction MI The study uses DNA samples obtained during a population-based case-control study in Costa Rica of 2150 subjects who experienced myocardial infarctions and 2150 matched controls Biochemical measurements dietary data and general information are available for this population One unique aspect of the study is that adipose tissue biomarkers of polyunsaturated FAs will be used to evaluate dietary exposure variables Adipose tissue biomarkers ie alpha-linolenic and linoleic acid are very good indicators of intake in this population Furthermore this study showed that increased levels of these biomarkers in adipose tissue are strongly associated with decreased risk of MI whereas an increase in 182 trans FAs increase the risk of MI Gene-diet association studies and a candidate pathway approach will be used to elucidate genetic mechanisms that link risk of MI with exposure to polyunsaturated FAs including cis and trans isomers of linoleic acid n-6 and alpha-linolenic acid n-3 The focus will be on peroxisome proliferator-activated receptor PPAR genes and PPAR-regulated genes that are involved in vascular inflammation Among controls the investigators will examine whether genetic and dietary factors independently affect biochemical markers phenotypes of the proposed genes They will also test whether these phenotypes are more clearly identified when genetic and dietary factors are examined together Because polyunsaturated FAs are important as activators of PPARs and their capacity to regulate gene expression at the level of transcription this metabolic system is a suitable candidate for the study
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL071888 | NIH | None | httpsreporternihgovquickSearchR01HL071888 |