Ignite Creation Date:
2024-05-05 @ 10:00 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001294
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Genetic Factors and Interrelationships for Sexual Orientation Susceptibility to HIV and Kaposis Sarcoma Alcoholism and Psychological Traits and Histocompatibility Antigens
Sponsor:
National Cancer Institute NCI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Genetic Factors and Interrelationships for Sexual Orientation Susceptibility to HIV and Kaposis Sarcoma Alcoholism and Psychological Traits and Histocompatibility Antigens
Status:
COMPLETED
Status Verified Date:
2005-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
We propose to test by DNA linkage analysis of family pedigree members the following interrelated hypotheses 1 that sexual orientation is genetically influenced 2 that the development of Kaposis sarcoma and other outcomes of HIV infection in male homosexuals is affected by host susceptibility genes circulating sex hormone levels or HLA haplotype and 3 that alcoholism and other psychobehavioral conditions are associated with homosexuality on a genetic basis andor influenced by candidate behavioral loci The subjects for these studies will be self-identified male and female homosexual probands and their relatives from families in which there are at least two individuals with homosexual orientation All subjects will be adults and will be referred through NIH physicians private practitioners and gay and lesbian organizations Subjects will undergo a sexual orientation and behaviors interview a psychiatric interview and phlebotomy for HIV testing HLA determination endocrine measurements and preparation of DNA from cultured lymphocytes The DNA samples will be analyzed for a series of genetic markers that span the human genome and for candidate loci chosen for function
Detailed Description:
We propose to test by DNA linkage analysis of family pedigree members the following interrelated hypotheses 1 that sexual orientation is genetically influenced 2 that the development of Kaposis sarcoma and other outcomes of HIV infection in male homosexuals is affected by host susceptibility genes circulating sex hormone levels or HLA haplotype and 3 that alcoholism and other psychobehavioral conditions are associated with homosexuality on a genetic basis andor influenced by candidate behavioral loci The subjects for these studies will be self-identified male and female homosexual probands and their relatives from families in which there are at least two individuals with homosexual orientation All subjects will be adults and will be referred through NIH physicians private practitioners and gay and lesbian organizations Subjects will undergo a sexual orientation and behaviors interview a psychiatric interview and phlebotomy for HIV testing HLA determination endocrine measurements and preparation of DNA from cultured lymphocytes The DNA samples will be analyzed for a series of genetic markers that span the human genome and for candidate loci chosen for function
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 92-C-0078 | None | None | None |