Ignite Creation Date:
2024-05-05 @ 11:25 PM
Last Modification Date:
2024-10-26 @ 10:33 AM
Study NCT ID:
NCT01329471
Status:
UNKNOWN
Last Update Posted:
2011-04-06
First Post:
2011-03-10
Brief Title:
Functional Role of RUNX1 Mutations in the Etiology of Acute Myeloid Leukemia AML
Sponsor:
Hillel Yaffe Medical Center
Organization:
Hillel Yaffe Medical Center
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2011-04
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to elucidate the role of RUNX1 in Acute Myeloid Leukemia AML in particular the transcriptional regulation of genes by mutated forms of this protein This research will study the effect of mutations found in AML patients
Detailed Description:
The RUNX1 gene located at chromosomal band 21q22 is a transcription factor crucial for hematopoiesis and the generation of hematopoietic stem cells in the embryo RUNX1 is the most frequent target for chromosomal translocation in leukemia In addition point mutations in the RUNX1 gene have been found to constitute an important mode of genetic alteration in development of leukemia Recent publications stressing the clinical need for implementing RUNX1 point mutations as both a diagnostic and unfavorable prognostic marker of AML have aroused particular interest in the functional role of RUNX1 in this disease
In order to pinpoint specific RUNX1 target genes involved in pre-leukemic transformation or exacerbation of existing leukemia the investigators plan to compare expression profiles from human hematopoietic progenitors overexpressing a mutated form of RUNX1with controls RUNX1 wild-type and knocked-down In this study the investigators intend to collect blood after receiving informed consent from umbilical cords of neonates born vaginally in order to isolate CD34 hematopoietic progenitors Human umbilical cord blood contains relatively high numbers of CD34 cells which may be frozen directly after collection and used as a source of progenitor cells for further culture or direct analysis
In order to pinpoint specific RUNX1 target genes involved in pre-leukemic transformation or exacerbation of existing leukemia the investigators plan to compare expression profiles from human hematopoietic progenitors overexpressing a mutated form of RUNX1with controls RUNX1 wild-type and knocked-down In this study the investigators intend to collect blood after receiving informed consent from umbilical cords of neonates born vaginally in order to isolate CD34 hematopoietic progenitors Human umbilical cord blood contains relatively high numbers of CD34 cells which may be frozen directly after collection and used as a source of progenitor cells for further culture or direct analysis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None