Ignite Creation Date:
2024-05-05 @ 11:34 AM
Last Modification Date:
2024-10-26 @ 9:09 AM
Study NCT ID:
NCT00072813
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2003-11-10
Brief Title:
MRI in Autosomal Dominant Partial Epilepsy With Auditory Features
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
MRI in Autosomal Dominant Partial Epilepsy With Auditory Features
Status:
COMPLETED
Status Verified Date:
2009-11-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will examine the possible structural and functional abnormalities in patients with an inherited form of epilepsy It will use magnetic resonance imaging MRI Uncontrolled epilepsy is a serious neurological problem with major harmful medical social and psychological effects as well as greater mortality compared with the general population The cost per year in the United States is at least 125 billion There have been advances in diagnosing the disease but the cause cannot be determined in many cases Recently several seizure syndromes found in families have been described One syndrome of particular interest involves the lateral temporal lobe of the brain and often includes auditory features Patients with that kind of syndrome may hear monotonous unformed sounds but sometimes they may hear complex sounds such as a song
Patients are eligible for this study if they have a specific form of familial epilepsy that is being studied at Columbia University in New York Family members without seizures are eligible as well All the patients in the study will be evaluated at Columbia before participating Healthy volunteers aged 18 to 55 also may be eligible for this study
Participants will undergo a medical history and physical examination During the study they may have three or four sessions of MRI During the MRI patients will lie still on a table that can slide in and out of a metal cylinder surrounded by a strong magnetic field Scanning time varies from 20 minutes to 3 hours with most scans lasting between 45 and 90 minutes Patients may be asked to lie still for up to 60 minutes at a time As the scanner takes pictures there will be loud knocking noises and the patients will wear earplugs to muffle the sound Patients will be able to communicate with the MRI staff at all times during the scan and may ask to be moved out of the machine at any time Some scans may be done in a 3 Tesla scanner It is the latest advance in MRI with a stronger magnetic field than in the more common 15 Tesla scanner Functional MRI fMRI is done while patients are performing tasks such as moving a limb or speaking Patients will have an opportunity to practice such tasks before entering the scanner The fMRI will take about 1 hour
Patients are eligible for this study if they have a specific form of familial epilepsy that is being studied at Columbia University in New York Family members without seizures are eligible as well All the patients in the study will be evaluated at Columbia before participating Healthy volunteers aged 18 to 55 also may be eligible for this study
Participants will undergo a medical history and physical examination During the study they may have three or four sessions of MRI During the MRI patients will lie still on a table that can slide in and out of a metal cylinder surrounded by a strong magnetic field Scanning time varies from 20 minutes to 3 hours with most scans lasting between 45 and 90 minutes Patients may be asked to lie still for up to 60 minutes at a time As the scanner takes pictures there will be loud knocking noises and the patients will wear earplugs to muffle the sound Patients will be able to communicate with the MRI staff at all times during the scan and may ask to be moved out of the machine at any time Some scans may be done in a 3 Tesla scanner It is the latest advance in MRI with a stronger magnetic field than in the more common 15 Tesla scanner Functional MRI fMRI is done while patients are performing tasks such as moving a limb or speaking Patients will have an opportunity to practice such tasks before entering the scanner The fMRI will take about 1 hour
Detailed Description:
Objectives to study potential structural and functional abnormalities in patients with an inherited form of epilepsy
Study Population Patients with autosomal dominant partial epilepsy with auditory features a newly described syndrome asymptomatic family members who are gene carriers and unaffected family members and normal volunteers
Design magnetic resonance imaging electroencephalography and magnetoencephalography
Outcome measures detection of structural lesions regional activation patterns on fMRI
Study Population Patients with autosomal dominant partial epilepsy with auditory features a newly described syndrome asymptomatic family members who are gene carriers and unaffected family members and normal volunteers
Design magnetic resonance imaging electroencephalography and magnetoencephalography
Outcome measures detection of structural lesions regional activation patterns on fMRI
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 04-N-0033 | None | None | None |