Ignite Creation Date:
2024-05-05 @ 11:30 PM
Last Modification Date:
2024-10-26 @ 10:34 AM
Study NCT ID:
NCT01345760
Status:
COMPLETED
Last Update Posted:
2012-10-16
First Post:
2011-04-29
Brief Title:
Expression Levels of RISC and Microprocessor Complex Components in Epithelial Skin Cancer
Sponsor:
Ruhr University of Bochum
Organization:
Ruhr University of Bochum
Study Overview
Official Title:
Expression Levels of RNA-induced Silencing Complex RISC Components TARBP1 TARBP2 Argonaute-1 Argonaute-2 PACT and Microprocessor Complex Component DGCR8 in Epithelial Skin Cancer
Status:
COMPLETED
Status Verified Date:
2012-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
MicroRNAs miRNAs are very small endogenous RNA molecules about 22-25 nucleotides in length capable of post-transcriptional gene regulation miRNAs bind to their target messenger RNAs mRNAs leading to cleavage or suppression of target mRNA translation based on the degree of complementarity miRNAs have recently been shown to play pivotal roles in diverse developmental and cellular processes and linked to a variety of skin diseases and cancers In the present study the investigators examines the expression profiles of the microprocessor complex subunit DGCR8 and the RISC components TARBP1 TARBP2 argonaute-1 argonaute-2 and PACT in epithelial skin cancer and its premalignant stage
Detailed Description:
Patients with premalignant actinic keratoses basal cell carcinomas and squamous cell carcinomas were included in the study Punch biopsies were harvested from the center of the tumors from sites of healthy skin and a healthy control group DGCR8 TARBP1 TARBP2 argonaute-1 argonaute-2 and PACT mRNA expression levels were detected by quantitative real-time reverse transcriptase polymerase chain reaction
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None