Ignite Creation Date:
2024-05-05 @ 11:33 PM
Last Modification Date:
2024-10-26 @ 10:35 AM
Study NCT ID:
NCT01357005
Status:
UNKNOWN
Last Update Posted:
2011-05-20
First Post:
2010-12-29
Brief Title:
Expanding Rapid Ascertainment Networks of Schizophrenia Families in Taiwan
Sponsor:
Far Eastern Memorial Hospital
Organization:
Far Eastern Memorial Hospital
Study Overview
Official Title:
Expanding Rapid Ascertainment Networks of Schizophrenia Families in Taiwan
Status:
UNKNOWN
Status Verified Date:
2011-05
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This proposal responds to Request for Applications RFA-MH-08-131 which seeks applications that propose to enrich pre-existing resources for schizophrenia in the NIMH Human Genetics Initiative and to apply genomic methods to further our understanding of the molecular etiology of the disorder The overarching aims of this proposal are to quickly and cost-effectively ascertain a large sample of trio families affected by schizophrenia and to discover causal variants for the disorder in the first family-based genome-wide association study GWAS of the disorder In Taiwan there is no such kind of policy to support this kind of GWAS study as it is a very expensive study including collecting large family samples and genome-wide SNP scanning The investigators thus collaborate with Professor Ming T Tsuang and his intended subcontracted researchers to apply for this project The investigators the research team in Taiwan will collect 3800 trio families 11400 subjects of schizophrenia
The investigators will meet the overarching goals of this project by accomplishing several Specific Aims as follows 1 Rapidly ascertain schizophrenia trio families from Taiwanese clinical ascertainment sites 2 Supplement NIMH Genetics Initiative collections by sending all clinical data and biomaterials to the appropriate repositories 3 Assess the association of schizophrenia with a genome-wide panel of single-nucleotide polymorphisms SNPs and their constituent haplotypes 4 Analyze quantitative schizophrenia phenotypes such as age at onset 5 Perform a genome-wide survey for copy-number variations related to schizophrenia 6 Test for gene-gene interactions epistasis and 7 Test for gene-environment interactions such as the well-established effect of season of birth
The investigators will meet the overarching goals of this project by accomplishing several Specific Aims as follows 1 Rapidly ascertain schizophrenia trio families from Taiwanese clinical ascertainment sites 2 Supplement NIMH Genetics Initiative collections by sending all clinical data and biomaterials to the appropriate repositories 3 Assess the association of schizophrenia with a genome-wide panel of single-nucleotide polymorphisms SNPs and their constituent haplotypes 4 Analyze quantitative schizophrenia phenotypes such as age at onset 5 Perform a genome-wide survey for copy-number variations related to schizophrenia 6 Test for gene-gene interactions epistasis and 7 Test for gene-environment interactions such as the well-established effect of season of birth
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None