Ignite Creation Date:
2024-05-05 @ 11:34 AM
Last Modification Date:
2024-10-26 @ 9:10 AM
Study NCT ID:
NCT00081679
Status:
COMPLETED
Last Update Posted:
2014-04-16
First Post:
2004-04-19
Brief Title:
SES Health Behaviors and CVD Among Vietnam-Era Twins
Sponsor:
The Miriam Hospital
Organization:
The Miriam Hospital
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2008-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To further characterize the nature of the association between socioeconomic status SES health behaviors and early cardiovascular disease in the Vietnam Era Twin VET Registry a sample of over 4000 twin pairs
Detailed Description:
BACKGROUND
Cardiovascular disease CVD affects approximately 60800000 Americans each year claiming the lives of nearly one million of these people American Heart Association 2001 CVD is likely to be complex in etiology reflecting the combined effect of both genes and environment as well as gene x gene and gene x environment interaction Examination of environmental factors thought to affect CVD risk in the context of a genetically informative design can help elucidate the relative contribution of genetic and environmental factors and potentially aid in identifying environmental factors that may interact with genetic vulnerability in predicting CVD Cardiovascular morbidity and mortality are over-represented among individuals in lower socioeconomic strata as are behaviors that increase the likelihood of cardiovascular events including smoking heavy alcohol consumption and physical inactivity Adler et al 1994 Anderson Armstead 1995 Thus it is commonly assumed that socioeconomic status SES serves as an important environmental influence on health and health behaviors Twin studies partition genetic and environmental variance and detect gene x environment interaction and provide a unique opportunity to study the association between SES and health
DESIGN NARRATIVE
The study will characterize the nature of the association between socioeconomic status SES health behaviors and cardiovascular disease CVD in the existing Vietnam Era Twin VET registry a sample of over 4000 male twin pairs with a mean age of 51 in 1999 Specifically the study will 1 determine how strongly environmental factors contribute to individual differences in SES health behaviors and CVD relative to genetic factors 2 examine whether measures of SES are associated with health behaviors and CVD mortality when controlling for concomitant genetic influences and 3 investigate whether SES interacts with genetic vulnerabilities to predict health behaviors and CVD gene x environment interaction Using VETdatasets the primary method of analysis will be twin structural equation modeling
Cardiovascular disease CVD affects approximately 60800000 Americans each year claiming the lives of nearly one million of these people American Heart Association 2001 CVD is likely to be complex in etiology reflecting the combined effect of both genes and environment as well as gene x gene and gene x environment interaction Examination of environmental factors thought to affect CVD risk in the context of a genetically informative design can help elucidate the relative contribution of genetic and environmental factors and potentially aid in identifying environmental factors that may interact with genetic vulnerability in predicting CVD Cardiovascular morbidity and mortality are over-represented among individuals in lower socioeconomic strata as are behaviors that increase the likelihood of cardiovascular events including smoking heavy alcohol consumption and physical inactivity Adler et al 1994 Anderson Armstead 1995 Thus it is commonly assumed that socioeconomic status SES serves as an important environmental influence on health and health behaviors Twin studies partition genetic and environmental variance and detect gene x environment interaction and provide a unique opportunity to study the association between SES and health
DESIGN NARRATIVE
The study will characterize the nature of the association between socioeconomic status SES health behaviors and cardiovascular disease CVD in the existing Vietnam Era Twin VET registry a sample of over 4000 male twin pairs with a mean age of 51 in 1999 Specifically the study will 1 determine how strongly environmental factors contribute to individual differences in SES health behaviors and CVD relative to genetic factors 2 examine whether measures of SES are associated with health behaviors and CVD mortality when controlling for concomitant genetic influences and 3 investigate whether SES interacts with genetic vulnerabilities to predict health behaviors and CVD gene x environment interaction Using VETdatasets the primary method of analysis will be twin structural equation modeling
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL072819 | NIH | None | httpsreporternihgovquickSearchR01HL072819 |