Ignite Creation Date:
2024-05-05 @ 11:35 AM
Last Modification Date:
2024-10-26 @ 9:10 AM
Study NCT ID:
NCT00083850
Status:
COMPLETED
Last Update Posted:
2016-07-29
First Post:
2004-06-02
Brief Title:
Genetics and Cardiovascular Reactivity in Young Twins
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2008-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To evaluate the effects of genetic variants in all of the nine adrenergic receptor subtype genes alone or in combination on cardiovascular reactivity and other quantitative cardiovascular traits in a population of 1048 healthy young twins
Detailed Description:
BACKGROUND
Several studies have shown that cardiovascular reactivity CVR to acute laboratory stress is a stable and heritable trait and predictive of future blood pressure BP levels and essential hypertension EH The sympathetic nervous system SNS has a major role in BP regulation and adrenergic receptor subtypes mediate BP responses to acute challenges As such our hypothesis is that individual differences in CVR are partly determined by variation in genes encoding for adrenergic receptors mediating the sympathoadrenal response to stress There is increasing evidence that this cardiovascular response is regulated by multiple adrenoceptor subtypes with structural homology To date nine homologous adrenergic receptor subtypes have been described Only one study has found a gene-gene interaction upon CV disease incorporating two adrenergic receptor subtypes Genetic variants in all the nine adrenergic receptor subtypes have never before been investigated in a single study as this study will do
DESIGN NARRATIVE
The study will evaluate the effects of genetic variants in all of the nine adrenergic receptor subtype genes alone or in combination on CVR and other quantitative cardiovascular traits in a population of 1048 healthy youth Subjects are black and white twins that have already been comprehensively phenotyped as part of the Georgia Cardiovascular Twin Study HL56622 Racial differences in adrenoceptor gene effects will receive special attention because such differences may offer a partial explanation for the higher prevalence of essential hypertension EH in blacks Primary measures are systolic BP at rest and in response to two behavioral stressors Secondary measures are diastolic BP cardiac output and total peripheral resistance TPR at rest and in response to the stressors left ventricular mass LVM endothelium dependent arterial dilation to reactive hyperemia EDAD arterial stiffness and 24-hour ambulatory BP This data set will be expanded through collection of buccal cell DNA from the parents of the twins enabling performance of TDTs transmission disequilibrium tests and haplotype reconstruction and analyses This candidate gene study in a large group of black and white twins including TDT and haplotype analyses provides an innovative approach to help identify individuals at particular risk for the development of EH and improve options for primary prevention as well as individualized therapy of EH pharmacogenetics
Several studies have shown that cardiovascular reactivity CVR to acute laboratory stress is a stable and heritable trait and predictive of future blood pressure BP levels and essential hypertension EH The sympathetic nervous system SNS has a major role in BP regulation and adrenergic receptor subtypes mediate BP responses to acute challenges As such our hypothesis is that individual differences in CVR are partly determined by variation in genes encoding for adrenergic receptors mediating the sympathoadrenal response to stress There is increasing evidence that this cardiovascular response is regulated by multiple adrenoceptor subtypes with structural homology To date nine homologous adrenergic receptor subtypes have been described Only one study has found a gene-gene interaction upon CV disease incorporating two adrenergic receptor subtypes Genetic variants in all the nine adrenergic receptor subtypes have never before been investigated in a single study as this study will do
DESIGN NARRATIVE
The study will evaluate the effects of genetic variants in all of the nine adrenergic receptor subtype genes alone or in combination on CVR and other quantitative cardiovascular traits in a population of 1048 healthy youth Subjects are black and white twins that have already been comprehensively phenotyped as part of the Georgia Cardiovascular Twin Study HL56622 Racial differences in adrenoceptor gene effects will receive special attention because such differences may offer a partial explanation for the higher prevalence of essential hypertension EH in blacks Primary measures are systolic BP at rest and in response to two behavioral stressors Secondary measures are diastolic BP cardiac output and total peripheral resistance TPR at rest and in response to the stressors left ventricular mass LVM endothelium dependent arterial dilation to reactive hyperemia EDAD arterial stiffness and 24-hour ambulatory BP This data set will be expanded through collection of buccal cell DNA from the parents of the twins enabling performance of TDTs transmission disequilibrium tests and haplotype reconstruction and analyses This candidate gene study in a large group of black and white twins including TDT and haplotype analyses provides an innovative approach to help identify individuals at particular risk for the development of EH and improve options for primary prevention as well as individualized therapy of EH pharmacogenetics
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R21HL076723 | NIH | None | httpsreporternihgovquickSearchR21HL076723 |