Ignite Creation Date:
2024-05-05 @ 10:00 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005003
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2000-03-23
Brief Title:
Genetic Component of Handedness
Sponsor:
National Cancer Institute NCI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Mapping the Genetic Component of Hand-Use Preference
Status:
COMPLETED
Status Verified Date:
2006-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Some functions are generally controlled by the right side of the brain and others by the left One of the most easily observed examples of this lateral specialization of the brain is handedness-that is a persons preference for using either the right or the left hand This study will try to determine how the genetic component of handedness is inherited It will test the theory that a single gene is involved in determining handedness and will try to locate the gene
Families with at least two left-handed siblings aged eight years or older and at least one right-handed parent are eligible to participate in this study
The left-handed siblings and both parents will fill out a brief questionnaire on hand usage obtain a tissue sample taken from inside the cheek and return the questionnaire and the sample by mail to the study researchers The tissue sample will be used for DNA gene mapping
Participants will be given a kit and instructions for obtaining the sample along with mailing envelopes Cheek swab sampling basically involves using a small brush to gently brush a layer of cells off of the inner wall of the cheek and then dropping the brush tip into a preservative
The information gained from this study may provide insight into aspects of brain development that can be of medical benefit in the future
Families with at least two left-handed siblings aged eight years or older and at least one right-handed parent are eligible to participate in this study
The left-handed siblings and both parents will fill out a brief questionnaire on hand usage obtain a tissue sample taken from inside the cheek and return the questionnaire and the sample by mail to the study researchers The tissue sample will be used for DNA gene mapping
Participants will be given a kit and instructions for obtaining the sample along with mailing envelopes Cheek swab sampling basically involves using a small brush to gently brush a layer of cells off of the inner wall of the cheek and then dropping the brush tip into a preservative
The information gained from this study may provide insight into aspects of brain development that can be of medical benefit in the future
Detailed Description:
The purpose of this protocol based on the hypothesis that human hand-use preference handedness is largely dependent on the action of a single locus is to collect samples allowing us to map a handedness gene via detection of linkage to any of eight potential candidate genesregions or via a whole or partial genome scan We calculate that a full 300 marker genome scan of 100 parents and sibling pairs allowing linkage analysis at 10 cM resolution or the equivalent amount of data from partial scans of 300 families has a high likelihood of allowing us to map the proposed gene Eligible families consisting of pairs of left-handed siblings plus at least one right-handed parent were identified during Phase I of this study in 1996-1998 with approval from the now-lapsed FCRDC IRB In Phase II of this study we have collected cheek swab samples for DNA isolation from members of 100 eligible families for use in the mapping studies DNA samples will not be linked back to individuals but grouped under a random family code that links to a database with limited information including hand use preference and family structure In the next phase we wish to map the locus from cheek swab samples we have on hand
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 00-C-0094 | None | None | None |