Ignite Creation Date:
2024-05-05 @ 10:00 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005500
Status:
COMPLETED
Last Update Posted:
2017-10-24
First Post:
2000-05-25
Brief Title:
Collaborative Studies on the Genetics of Asthma CSGA
Sponsor:
University of Minnesota
Organization:
University of Minnesota
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2017-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To conduct molecular genetic studies in human pedigrees in order to identify the major genes responsible for asthma
Detailed Description:
BACKGROUND
Asthma is a respiratory disease characterized by variable airways obstruction airways inflammation and bronchial hyperresponsiveness BHR There are recent increases in asthma mortality and prevalence in the US especially in African-Americans Multiple studies suggest that both genetic and environmental factors are important in asthma susceptibility
The study was recommended by the Pulmonary Diseases Advisory Committee at its February 1991 meeting and given concept approval by the May 1991 National Heart Lung and Blood Advisory Council The Request for Applications was released in October 1992
DESIGN NARRATIVE
The CSGA was composed of five centers Johns Hopkins University University of Chicago University of Maryland University of Minnesota and a data coordinating center at Wake Forest At each center families were ascertained through two siblings with asthma All family members were characterized with spirometry bronchial responsiveness to methacholine or reversibility testing skin-tests and questionnaire data The initial genome screen was completed on the first 237 sib pairs from three racial groups African-American Caucasian and Hispanic and genotyping on the remaining family members and families was completed before the study was renewed in 1997 Therefore the initial aim of the CSGA to map susceptibility regions was completed with detection of several novel chromosomal regions and replication of several regions previously linked to associated phenotypes
In order to determine the importance of these regions in asthma susceptibility and the impact of environmental rink factors the investigators l evaluated the evidence for linkage in the complete CSGA data using 2-point multipoint and multilocus approaches for asthma and associated phenotypes including BHR total serum IgE and skin test reactivity to standardized allergens 2 performed fine mapping studies of regions using additional genetic markers to obtain a 2 cM map 3 identified candidate genes and novel sequence variants and 4 characterized a patient population with asthma to study identified variants with respect to asthma severity and bronchial inflammation These studies allowed identification of asthma susceptibility genes and their variants interactions with other genes and environmental risk factors as well as provided insight for the development of improved treatment and ultimate prevention of asthma
Asthma is a respiratory disease characterized by variable airways obstruction airways inflammation and bronchial hyperresponsiveness BHR There are recent increases in asthma mortality and prevalence in the US especially in African-Americans Multiple studies suggest that both genetic and environmental factors are important in asthma susceptibility
The study was recommended by the Pulmonary Diseases Advisory Committee at its February 1991 meeting and given concept approval by the May 1991 National Heart Lung and Blood Advisory Council The Request for Applications was released in October 1992
DESIGN NARRATIVE
The CSGA was composed of five centers Johns Hopkins University University of Chicago University of Maryland University of Minnesota and a data coordinating center at Wake Forest At each center families were ascertained through two siblings with asthma All family members were characterized with spirometry bronchial responsiveness to methacholine or reversibility testing skin-tests and questionnaire data The initial genome screen was completed on the first 237 sib pairs from three racial groups African-American Caucasian and Hispanic and genotyping on the remaining family members and families was completed before the study was renewed in 1997 Therefore the initial aim of the CSGA to map susceptibility regions was completed with detection of several novel chromosomal regions and replication of several regions previously linked to associated phenotypes
In order to determine the importance of these regions in asthma susceptibility and the impact of environmental rink factors the investigators l evaluated the evidence for linkage in the complete CSGA data using 2-point multipoint and multilocus approaches for asthma and associated phenotypes including BHR total serum IgE and skin test reactivity to standardized allergens 2 performed fine mapping studies of regions using additional genetic markers to obtain a 2 cM map 3 identified candidate genes and novel sequence variants and 4 characterized a patient population with asthma to study identified variants with respect to asthma severity and bronchial inflammation These studies allowed identification of asthma susceptibility genes and their variants interactions with other genes and environmental risk factors as well as provided insight for the development of improved treatment and ultimate prevention of asthma
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| U01HL049609 | NIH | None | httpsreporternihgovquickSearchU01HL049609 |