Ignite Creation Date:
2024-05-05 @ 11:38 AM
Last Modification Date:
2024-10-26 @ 9:11 AM
Study NCT ID:
NCT00096564
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2004-11-10
Brief Title:
Brain Activities Associated With Different Facial Expressions Using Blood Oxygenation Level Dependent Functional MRI
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Functional MRI Study of Brain Activation With Observation of Facial Expressions
Status:
COMPLETED
Status Verified Date:
2008-08-20
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Objectives The purpose of this study is to identify areas of brain activation during the urge to yawn Little is known about how yawning is suppressed or why yawning often occurs in response to seeing another person yawn contagious yawning Contagious yawning is similar to other contagious motor programs such as the greater urge Tourette subjects feel to tic when seeing repetitive movements or other subjects tics the urge to scratch when discussing itching and scratching or the urge to urinate when hearing running water Hypothetically the urge or the suppression of this urge is modulated by a common cortical circuit implicated in Tourette syndrome We plan to use functional magnetic resonance imaging fMRI to identify the pattern of blood oxygenation level-dependent BOLD activation in the brain when normal volunteers feel the urge to yawn
Study Population We intend to study 25 normal right-handed healthy volunteers
Study Design Using an event-related design we will scan subjects using the same 3T fMRI scanner while showing a video of a person yawning gaping coughing or doing nothing Each of these four action stimuli will last for four seconds with varying interstimulus intervals Each video set will contain all actions displayed ten times pseudorandomly Two data sets will be collected from each subject and will be separated by a brief rest period Subjects will be instructed before the scan to watch a videotaped person perform various behaviors without detailing the specific actions So as not to influence their natural response to the yawning stimulus we will instruct them only to keep their head still The variable of interest will be the activation during urge-generation contrasted with other control stimuli A survey will be administered for informational purposes following the scan to assess the subjects general impression of their susceptibility to yawning whether they yawned in the scanner whether they suppressed the urge to yawn and if the urge to yawn increased or decreased with the repetition of the yawning segment
Outcome Measures The primary outcome of this study is the activation of brain structures in response to viewing another person yawning In particular we are interested in the activation of the anterior cingulate cortex parietal operculum insula supplementary motor area and dorsolateral prefrontal cortex as these are areas implicated in the urge to move in response to either internal as in Tourette syndrome or external as in itching from histamine injection states Since the urge to yawn is the process of interest suppression of yawning is not relevant to the fMRI analysis
Study Population We intend to study 25 normal right-handed healthy volunteers
Study Design Using an event-related design we will scan subjects using the same 3T fMRI scanner while showing a video of a person yawning gaping coughing or doing nothing Each of these four action stimuli will last for four seconds with varying interstimulus intervals Each video set will contain all actions displayed ten times pseudorandomly Two data sets will be collected from each subject and will be separated by a brief rest period Subjects will be instructed before the scan to watch a videotaped person perform various behaviors without detailing the specific actions So as not to influence their natural response to the yawning stimulus we will instruct them only to keep their head still The variable of interest will be the activation during urge-generation contrasted with other control stimuli A survey will be administered for informational purposes following the scan to assess the subjects general impression of their susceptibility to yawning whether they yawned in the scanner whether they suppressed the urge to yawn and if the urge to yawn increased or decreased with the repetition of the yawning segment
Outcome Measures The primary outcome of this study is the activation of brain structures in response to viewing another person yawning In particular we are interested in the activation of the anterior cingulate cortex parietal operculum insula supplementary motor area and dorsolateral prefrontal cortex as these are areas implicated in the urge to move in response to either internal as in Tourette syndrome or external as in itching from histamine injection states Since the urge to yawn is the process of interest suppression of yawning is not relevant to the fMRI analysis
Detailed Description:
Purpose of this study
This study will look at how perception and observation of various facial expressions may affect the way different areas of the brain function We hope to gain a greater understanding of abnormal movements such as tics by investigating how facial expressions affect the brain
Background Information
This study is based on prior research that focuses on the activity and changes in different areas of the brain depending on what people see others around them doing An example is the feeling of empathy one might have when looking at a sad face or anxiety and fear when looking at an angry face
Who is the Study Population
20 healthy right-handed men and women
This study will look at how perception and observation of various facial expressions may affect the way different areas of the brain function We hope to gain a greater understanding of abnormal movements such as tics by investigating how facial expressions affect the brain
Background Information
This study is based on prior research that focuses on the activity and changes in different areas of the brain depending on what people see others around them doing An example is the feeling of empathy one might have when looking at a sad face or anxiety and fear when looking at an angry face
Who is the Study Population
20 healthy right-handed men and women
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 05-N-0032 | None | None | None |