Ignite Creation Date:
2024-05-05 @ 10:00 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005691
Status:
COMPLETED
Last Update Posted:
2016-03-16
First Post:
2000-05-25
Brief Title:
Psychosocial Risk Factors for Coronary Heart Disease in Swedish Women
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2001-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To study psychosocial risk factors for coronary heart disease in Swedish women
Detailed Description:
BACKGROUND
The incidence of non-fatal myocardial infarction in Swedish women below age 60 increased during the past 20 years Standard risk factor change includes a decrease in average systolic blood pressure and S-cholesterol but a moderate increase in smoking and diabetes prevalence During the same time period Swedish women have moved into the labor market so that employment rates are now similar in Swedish men and women However women have kept the main responsibilities for household and child care In spite of generous legislation for maternity leave and child care the strains from multiple roles and responsibilities have probably increased in Swedish women The study sought to provide an answer to 1 which factors - biological and behavioral - influenced both the extent of and progress of coronary artery disease 2 which physiological biochemical or neuroendocrine mechanisms participated in the process In addition to conventional statistical methods canonical correlations analyses were used to describe direct and indirect pathways of the pathogenesis Furthermore by means of the two comparison groups information was obtained about the specific characteristics of the female psychosocial and behavioral coronary heart disease risk profile
DESIGN NARRATIVE
The role of social strain was studied within a broader psychosocial context including social networks social supports social skills reciprocity coping stressors chronic work strain family structure personality and behavior characteristics These aspects were related to possible physiologic cardiovascular mechanisms including reactivity of and persistent elevated heart rates and blood pressure on ambulatory monitoring as well as cardiac dysrhythmia and silent or symptomatic ischemia Psychoneuroendocrine pathways were also investigated These included catecholamines cortisol prolactin estrogen testosterone gastrin somatostatin Other biochemical measures included lipid profile coagulation thrombolysis and immune function These examinations were applied to all women below age 60 living in the greater Stockholm area with signs or symptoms of coronary heart disease The women were followed and reexamined including angiograms after 2 to 25 years They were compared to an equal number of age matched men and to an equal number of age matched healthy women from the same catchment area
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
The incidence of non-fatal myocardial infarction in Swedish women below age 60 increased during the past 20 years Standard risk factor change includes a decrease in average systolic blood pressure and S-cholesterol but a moderate increase in smoking and diabetes prevalence During the same time period Swedish women have moved into the labor market so that employment rates are now similar in Swedish men and women However women have kept the main responsibilities for household and child care In spite of generous legislation for maternity leave and child care the strains from multiple roles and responsibilities have probably increased in Swedish women The study sought to provide an answer to 1 which factors - biological and behavioral - influenced both the extent of and progress of coronary artery disease 2 which physiological biochemical or neuroendocrine mechanisms participated in the process In addition to conventional statistical methods canonical correlations analyses were used to describe direct and indirect pathways of the pathogenesis Furthermore by means of the two comparison groups information was obtained about the specific characteristics of the female psychosocial and behavioral coronary heart disease risk profile
DESIGN NARRATIVE
The role of social strain was studied within a broader psychosocial context including social networks social supports social skills reciprocity coping stressors chronic work strain family structure personality and behavior characteristics These aspects were related to possible physiologic cardiovascular mechanisms including reactivity of and persistent elevated heart rates and blood pressure on ambulatory monitoring as well as cardiac dysrhythmia and silent or symptomatic ischemia Psychoneuroendocrine pathways were also investigated These included catecholamines cortisol prolactin estrogen testosterone gastrin somatostatin Other biochemical measures included lipid profile coagulation thrombolysis and immune function These examinations were applied to all women below age 60 living in the greater Stockholm area with signs or symptoms of coronary heart disease The women were followed and reexamined including angiograms after 2 to 25 years They were compared to an equal number of age matched men and to an equal number of age matched healthy women from the same catchment area
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL045785 | NIH | None | httpsreporternihgovquickSearchR01HL045785 |