Ignite Creation Date:
2024-05-05 @ 11:38 AM
Last Modification Date:
2024-10-26 @ 9:11 AM
Study NCT ID:
NCT00098267
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2006-07-12
Brief Title:
Collection of Dental Plaque and Saliva for Studies of Bacterial Colonization of Teeth
Sponsor:
National Institute of Dental and Craniofacial Research NIDCR
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Collection of Dental Plaque and Saliva for Studies of Oral Microbial Colonization
Status:
COMPLETED
Status Verified Date:
2009-08-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will explore how bacteria colonize human teeth and how this process changes over the lifetime of individuals It will include an investigation of transmission of bacteria that initiate colonization between adults and from adults to infants
Selected NIH scientists and members of their immediate families including infants are eligible for this study Participants provide a small sample of saliva and a sample of bacteria collected by rubbing a cotton swab over the surfaces of the lower four incisors Adults collect and submit their own specimens a dentist collects specimens from children
Selected NIH scientists and members of their immediate families including infants are eligible for this study Participants provide a small sample of saliva and a sample of bacteria collected by rubbing a cotton swab over the surfaces of the lower four incisors Adults collect and submit their own specimens a dentist collects specimens from children
Detailed Description:
Interactions between different bacteria play an important role in biofilm development during primary colonization of the human tooth surface Well studied examples of such interactions include the receptor polysaccharide RPS-mediated interactions between viridans group streptococci and other oral bacteria including type 2 fimbriated Actinomyces naeslundii Previous studies have resulted in the identification of different structural antigenic and molecular types of RPS on the streptococci that initiate colonization of the tooth surface This information provides the basis for the current protocol which addresses a number of important questions involving the nature of the commensal relationship that exists between biofilm-forming bacteria and the host For example 1 How many types of RPS are produced by the resident flora of an individual at any one time 2 Does the resident population of RPS-producing clones change over the lifetime of the host 3 Do individuals produce secretory antibodies against bacterial RPS and if so does this drive a change in the antigenic type of RPS produced 3 When and how do infants acquire RPS-producing bacteria before or after tooth eruption To address these questions we wish to collect and analyze samples of early dental plaque from the members of individual families The collection of such samples will be accomplished by gently rubbing exposed tooth surfaces with a sterile cotton swab Adult volunteers will also be asked to provide small samples of saliva which will be assayed for the presence of specific anti-RPS antibodies The sampling procedures proposed in this protocol do not present any significant risk to either adult or infant volunteers The information gained from these studies although not directly beneficial to these individuals is expected to provide important insights into the commensal relationship that exists between biofilm-forming bacteria and the host This in turn will contribute to an improved understanding of variables associated with the maintenance of oral health and the initiation of disease
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 05-D-0051 | None | None | None |