Ignite Creation Date:
2024-05-05 @ 11:40 AM
Last Modification Date:
2024-10-26 @ 9:11 AM
Study NCT ID:
NCT00104585
Status:
COMPLETED
Last Update Posted:
2012-01-19
First Post:
2005-03-01
Brief Title:
Consortium On Risk for Early-onset Parkinsons Disease CORE PD
Sponsor:
Columbia University
Organization:
Columbia University
Study Overview
Official Title:
Genetic Epidemiology of Parkinsons Disease
Status:
COMPLETED
Status Verified Date:
2024-07
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to investigate genetic and environmental risk factors that increase susceptibility to the development of early-onset Parkinsons disease developed at or before age 50
Detailed Description:
Parkinsons disease PD is a common neurodegenerative condition Although mostly a late-onset disorder 10 percent of people with PD are reported to develop symptoms before the age of 50 To date six genes have been found to be associated with PD however the majority have been found in rare PD families Some studies have also identified a number of environmental risk factors such as pesticide use that appear to increase the risk of PD
In a previous study Dr Karen Marder and her research team found that close family members of people with both early- and late-onset PD have a three-fold increased risk of PD compared to close family members of people without PD
The purpose of the Consortium On Risk for Early-onset Parkinsons Disease CORE PD study is to identify the genetic factors that contribute to the development of early-onset Parkinsons disease and to understand how these genetic factors interact with other genes and the environment to cause PD
Participation in the study involves a blood draw to look for genetic factors associated with PD questionnaires collecting information on family and medical history and a neurological examination In addition participants may be contacted in the future and asked to participate in a more detailed interview At that time study investigators will also ask participants for permission to contact family members to invite them to participate in the study
This research study requires participants to sign a consent form which states that the research is voluntary and confidential In addition since this is a research study genetic results are not released to participants or their family members now or in the future
Scientists hope this multi-center study will increase the current knowledge of PD and that the identification of factors that cause PD will lead to better diagnosis and treatment
In a previous study Dr Karen Marder and her research team found that close family members of people with both early- and late-onset PD have a three-fold increased risk of PD compared to close family members of people without PD
The purpose of the Consortium On Risk for Early-onset Parkinsons Disease CORE PD study is to identify the genetic factors that contribute to the development of early-onset Parkinsons disease and to understand how these genetic factors interact with other genes and the environment to cause PD
Participation in the study involves a blood draw to look for genetic factors associated with PD questionnaires collecting information on family and medical history and a neurological examination In addition participants may be contacted in the future and asked to participate in a more detailed interview At that time study investigators will also ask participants for permission to contact family members to invite them to participate in the study
This research study requires participants to sign a consent form which states that the research is voluntary and confidential In addition since this is a research study genetic results are not released to participants or their family members now or in the future
Scientists hope this multi-center study will increase the current knowledge of PD and that the identification of factors that cause PD will lead to better diagnosis and treatment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01NS036630 | NIH | None | httpsreporternihgovquickSearchR01NS036630 |