Ignite Creation Date:
2024-05-05 @ 10:00 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005412
Status:
COMPLETED
Last Update Posted:
2016-05-13
First Post:
2000-05-25
Brief Title:
Dietary Antioxidants and Atherosclerosis
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2000-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To examine the role of dietary antioxidants in the etiology of atherosclerosis in both sexes and in whites and Blacks
Detailed Description:
BACKGROUND
Atherosclerosis is this nations leading cause of death for males and females and Blacks and whites There is mounting evidence that the oxidation of blood low density lipoproteins LDL plays an important role in the pathogenesis of this disease LDL oxidation can be prevented by several dietary antioxidants in particular vitamin C vitamin E and beta-carotene There is preliminary evidence that dietary antioxidants may slow the natural history of atherosclerosis in humans Until now studies in this area have included predominantly white males with symptomatic disease
DESIGN NARRATIVE
The case-control study used data collected in ARIC to test the hypothesis that individuals in the lowest quintile of vitamin C vitamin E and carotenoid consumption were at higher risk of asymptomatic atherosclerosis than those consuming greater amounts Antioxidant intake was assessed by a validated food frequency questionnaire and a diet supplement survey Cases were those with asymptomatic carotid artery atherosclerosis as determined by B-mode ultrasonography Controls were those without evidence of carotid artery atherosclerosis Secondary analyses determined which sex-race subgroups were at particular risk due to low antioxidant consumption
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Atherosclerosis is this nations leading cause of death for males and females and Blacks and whites There is mounting evidence that the oxidation of blood low density lipoproteins LDL plays an important role in the pathogenesis of this disease LDL oxidation can be prevented by several dietary antioxidants in particular vitamin C vitamin E and beta-carotene There is preliminary evidence that dietary antioxidants may slow the natural history of atherosclerosis in humans Until now studies in this area have included predominantly white males with symptomatic disease
DESIGN NARRATIVE
The case-control study used data collected in ARIC to test the hypothesis that individuals in the lowest quintile of vitamin C vitamin E and carotenoid consumption were at higher risk of asymptomatic atherosclerosis than those consuming greater amounts Antioxidant intake was assessed by a validated food frequency questionnaire and a diet supplement survey Cases were those with asymptomatic carotid artery atherosclerosis as determined by B-mode ultrasonography Controls were those without evidence of carotid artery atherosclerosis Secondary analyses determined which sex-race subgroups were at particular risk due to low antioxidant consumption
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R03HL047408 | NIH | None | httpsreporternihgovquickSearchR03HL047408 |