Ignite Creation Date:
2024-05-05 @ 11:40 AM
Last Modification Date:
2024-10-26 @ 9:11 AM
Study NCT ID:
NCT00104039
Status:
COMPLETED
Last Update Posted:
2019-11-05
First Post:
2005-02-19
Brief Title:
Brain Changes in Children and Adolescents With Behavioral Problems
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Investigating the Neuro-Cognitive Underpinnings of the Emotional Dysfunction Linked to Childhood Behavioral Disturbance
Status:
COMPLETED
Status Verified Date:
2016-07-21
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Purpose
This study will examine brain activity in children age 10-18 with disruptive behavior problems including conduct disorder CD oppositional defiant disorder ODD and attention deficit hyperactivity disorder ADHD compared with children without behavioral problems Our goal is to examine differences in how emotions social situations and problem-solving situations are processed in the brain across these groups of children
This study will examine brain activity in children age 10-18 with disruptive behavior problems including conduct disorder CD oppositional defiant disorder ODD and attention deficit hyperactivity disorder ADHD compared with children without behavioral problems Our goal is to examine differences in how emotions social situations and problem-solving situations are processed in the brain across these groups of children
Detailed Description:
OBJECTIVE
The goal of this protocol is to investigate the neuro-cognitive underpinnings of the emotional dysfunction linked to childhood behavioral disturbance in particular Conduct Disorder with elevated callous-unemotional CU traits CDCU Conduct Disorder with non elevated CU traits CD-CU but also ADHD The functional hypotheses that we are testing with both neuro-cognitive and neuro-imaging paradigms are that 1 CDCU but not ADHD is associated with dysfunction in the formation and operational use of stimulus-punishment and to a lesser extent stimulus-reward association information 2 CD-CU is associated with heightened threat sensitivity and impairment in executive systems involved in emotional regulation and 3 that ADHD and CD-CU is associated with impairment in executive systems related to the representation and execution of task demands
STUDY POPULATION
160 children with Conduct Disorder CD and high CU traits the CDCU group 160 children with CD and low CU traits the CD-CU group 160 children with ADHD and 160 healthy volunteer children All children will be between the ages of 10 and 17 Both males and females will be enrolled
DESIGN
The current study will have two phases i neuropsychological assessment and training in an MRI simulator up to 4 hours ii The MRI scanning session up to 2 hours no more than 90 minutes in scanner Participants if they are willing may be invited to participate in more than one scanning session up to a maximum of 3 120 minute sessions or neuro-cognitive testing session
OUTCOME MEASURES
Behaviorally we predict that children with CDCU and children with CD-CU will present with impairment on tasks that involve either the formation or operational use of particular stimulus-punishment associations eg the subjective value learning task and emotional interrupt task However the nature of this impairment with be qualitatively different For example we predict that youth with CDCU will show reduced interference by emotional distracters on the emotional interrupt task but that youth with CD-CU will show decreased interference In contrast we predict that children with ADHD but no CD will show no behavioral impairment on such tasks However we predict that children with ADHD and children with CD-CU will present with impairments on executive function tasks eg the Number Stroop paradigm In contrast we predict that children with CDCU will show no impairment on these tasks At the anatomical level we anticipate reduced activation of emotional related systems in children with CDCU but increased activation in children with CD-CU during emotional impact tasks in particular reduced activation of the amygdala regions of orbitofrontal cortex and anterior cingulate We anticipate that the neural response of children with ADHD during these tasks will be less anomalous We anticipate that the neural response of children with ADHD and children with CD-CU during the performance of response control tasks to be anomalous with considerable greater recruitment of anterior and posterior compensatory systems
The goal of this protocol is to investigate the neuro-cognitive underpinnings of the emotional dysfunction linked to childhood behavioral disturbance in particular Conduct Disorder with elevated callous-unemotional CU traits CDCU Conduct Disorder with non elevated CU traits CD-CU but also ADHD The functional hypotheses that we are testing with both neuro-cognitive and neuro-imaging paradigms are that 1 CDCU but not ADHD is associated with dysfunction in the formation and operational use of stimulus-punishment and to a lesser extent stimulus-reward association information 2 CD-CU is associated with heightened threat sensitivity and impairment in executive systems involved in emotional regulation and 3 that ADHD and CD-CU is associated with impairment in executive systems related to the representation and execution of task demands
STUDY POPULATION
160 children with Conduct Disorder CD and high CU traits the CDCU group 160 children with CD and low CU traits the CD-CU group 160 children with ADHD and 160 healthy volunteer children All children will be between the ages of 10 and 17 Both males and females will be enrolled
DESIGN
The current study will have two phases i neuropsychological assessment and training in an MRI simulator up to 4 hours ii The MRI scanning session up to 2 hours no more than 90 minutes in scanner Participants if they are willing may be invited to participate in more than one scanning session up to a maximum of 3 120 minute sessions or neuro-cognitive testing session
OUTCOME MEASURES
Behaviorally we predict that children with CDCU and children with CD-CU will present with impairment on tasks that involve either the formation or operational use of particular stimulus-punishment associations eg the subjective value learning task and emotional interrupt task However the nature of this impairment with be qualitatively different For example we predict that youth with CDCU will show reduced interference by emotional distracters on the emotional interrupt task but that youth with CD-CU will show decreased interference In contrast we predict that children with ADHD but no CD will show no behavioral impairment on such tasks However we predict that children with ADHD and children with CD-CU will present with impairments on executive function tasks eg the Number Stroop paradigm In contrast we predict that children with CDCU will show no impairment on these tasks At the anatomical level we anticipate reduced activation of emotional related systems in children with CDCU but increased activation in children with CD-CU during emotional impact tasks in particular reduced activation of the amygdala regions of orbitofrontal cortex and anterior cingulate We anticipate that the neural response of children with ADHD during these tasks will be less anomalous We anticipate that the neural response of children with ADHD and children with CD-CU during the performance of response control tasks to be anomalous with considerable greater recruitment of anterior and posterior compensatory systems
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 05-M-0105 | None | None | None |