Ignite Creation Date:
2024-05-05 @ 11:40 AM
Last Modification Date:
2024-10-26 @ 9:11 AM
Study NCT ID:
NCT00101517
Status:
COMPLETED
Last Update Posted:
2014-09-16
First Post:
2005-01-10
Brief Title:
Partnership Programs to Reduce Ethnic Differences in the Risk of Cardiovascular Disease
Sponsor:
Emory University
Organization:
Emory University
Study Overview
Official Title:
Partnership Programs to Reduce Cardiovascular Disparities - Morehouse-Emory Partnership
Status:
COMPLETED
Status Verified Date:
2014-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
META-HEALTH
Brief Summary:
The purpose of this study is to improve cardiovascular disease CVD outcomes in racial and ethnic minorities Specifically the study seeks to systematically characterize potential ethnic differences in obesity-related CVD by drawing upon the fields of psychology physiology biochemistry nursing and clinical medicine
Detailed Description:
BACKGROUND
While there has been great progress in reducing CVD morbidity and mortality in the US over the past 40 years some minority groups have not shared fully in this progress and continue to have lower life expectancy and higher CVD morbidity On average minorities have less access to medical care receive less aggressive care and fewer diagnostic and therapeutic cardiac procedures and adhere poorly to prescribed medical regimens Thus research to reduce health disparities by improving CVD outcomes in minorities offers potential for a substantial positive public heath impact Academic medical centers and institutions capable of carrying out such research however often lack access to and the trust of minority patients Minority patients often receive fragmented care because they lack access to regular medical care present to emergency departments rather than primary care physicians for complications of an advanced chronic CVD condition and are less likely to follow medical regimens Minority communities often harbor distrust of clinical research Minority patients report greater satisfaction when receiving care from minority providers and are reluctant to receive treatment outside their minority healthcare serving systems
In general minorities have high rates of hypertension elevated cholesterol cigarette smoking obesity metabolic syndrome and diabetes as well as other behavioral environmental and occupational risk factors for cardiovascular diseases such as sleep problems - all elements that contribute to excess CVD morbidity and mortality The causes of minority health disparities are complex and incompletely understood Although evidence of genetic biologic and environmental factors is well documented poor outcomes are also attributed to under-treatment Such under-treatment may be due to limited access to health care or in some cases break-down of the medical system or failure of the physician andor patient to allow for optimal health care even when access is not impaired The complex interactions of behavior socio-economic status SES culture and ethnicity are important predictors of health outcomes and sources of health disparities Despite efforts to elucidate genetic and environmental risk factors and to promote cardiovascular health in high-risk populations trends in CVD outcomes suggest that CVD health disparities continue to widen
The Partnerships Program to Reduce Cardiovascular Health Disparities involves collaboration between research-intensive medical centers RIMCs that have a track record of NIH-supported research and patient care and minority healthcare serving systems MSSs that lack a strong research program Each Partnership Program will a design and carry out multiple interdisciplinary research projects that investigate complex biological behavioraland societal factors that contribute to CVD health disparities and facilitate clinical research within the MSS to improve CVD outcomes and reduce health disparities and b provide reciprocal educational and skills development programs so that investigators will be able to conduct research aimed at reducing cardiovascular disparities and thereby enhance research opportunities enrich cultural sensitivity and improve cardiovascular research capabilities at both institutions
The Request for Applications for Partnership Programs to Reduce Cardiovascular Disparities was released in September 2003 The awards were made in September 2004
DESIGN NARRATIVE
Over the past decade there has been an explosive increase in obesity among all age groups within the US population This epidemic is particularly problematic among African Americans in the Southeast Although genetic factors play a contributory role it is postulated that ethnic disparities in obesity and obesity-related CVD are related to a dynamic interplay between biological factors and the behavioral response to the unique environmental context within ethnic communities Obesity is often associated with perturbations in the metabolic and physiologic milieu A cluster of obesity-related abnormalities has been defined as the Metabolic Syndrome The CVD complications of obesity appears to be related to the capacity for adipose tissue itself to generate adipokines that directly predispose to insulin-resistance endothelial dysfunction inflammation and vascular disease
The study will use state-of-the-art approaches to define potential ethnic differences in the profile of metabolic physiologic and biochemical features associated with obesity as well as the salutary responses to lifestyle modification The program uses a multi-disciplinary strategy to systematically characterize potential ethnic differences in obesity-related CVD by drawing upon the fields of psychology physiology biochemistry nursing and clinical medicine In a thematic series of inter-related studies the programs research plan ranges from epidemiology studies within the ethnic communities to patient-centered clinical trial interventions within ethnic community practices to the analysis of novel biomarkers of human pathobiology This collaborative multi-investigator team is built upon a complementary partnership between the Morehouse School of Medicine and Emory University This partnership shares a joint commitment to address the striking ethnic disparities in the high-risk CVD population The specific aims are 1 to define the relative influence of psychosocialcultural factors and biological mediators as determinants of ethnic disparities in obesity and the metabolic syndrome in a population-based bi-racial cohort 2 to define the effectiveness of patient-targeted behavioral interventions to enhance the health of African American patients with the Metabolic Syndrome in the context of community-based clinical practices 3 to assess the impact of innovative lifestyle intervention strategies on conventional and novel biomarkers of vascular disease risk in African Americans and 4 to enhance the educationtraining of fellowspractitioners engaged in CVD disparities researchpractice and promote partnerships that enhance cardiovascular health within ethnic communities
While there has been great progress in reducing CVD morbidity and mortality in the US over the past 40 years some minority groups have not shared fully in this progress and continue to have lower life expectancy and higher CVD morbidity On average minorities have less access to medical care receive less aggressive care and fewer diagnostic and therapeutic cardiac procedures and adhere poorly to prescribed medical regimens Thus research to reduce health disparities by improving CVD outcomes in minorities offers potential for a substantial positive public heath impact Academic medical centers and institutions capable of carrying out such research however often lack access to and the trust of minority patients Minority patients often receive fragmented care because they lack access to regular medical care present to emergency departments rather than primary care physicians for complications of an advanced chronic CVD condition and are less likely to follow medical regimens Minority communities often harbor distrust of clinical research Minority patients report greater satisfaction when receiving care from minority providers and are reluctant to receive treatment outside their minority healthcare serving systems
In general minorities have high rates of hypertension elevated cholesterol cigarette smoking obesity metabolic syndrome and diabetes as well as other behavioral environmental and occupational risk factors for cardiovascular diseases such as sleep problems - all elements that contribute to excess CVD morbidity and mortality The causes of minority health disparities are complex and incompletely understood Although evidence of genetic biologic and environmental factors is well documented poor outcomes are also attributed to under-treatment Such under-treatment may be due to limited access to health care or in some cases break-down of the medical system or failure of the physician andor patient to allow for optimal health care even when access is not impaired The complex interactions of behavior socio-economic status SES culture and ethnicity are important predictors of health outcomes and sources of health disparities Despite efforts to elucidate genetic and environmental risk factors and to promote cardiovascular health in high-risk populations trends in CVD outcomes suggest that CVD health disparities continue to widen
The Partnerships Program to Reduce Cardiovascular Health Disparities involves collaboration between research-intensive medical centers RIMCs that have a track record of NIH-supported research and patient care and minority healthcare serving systems MSSs that lack a strong research program Each Partnership Program will a design and carry out multiple interdisciplinary research projects that investigate complex biological behavioraland societal factors that contribute to CVD health disparities and facilitate clinical research within the MSS to improve CVD outcomes and reduce health disparities and b provide reciprocal educational and skills development programs so that investigators will be able to conduct research aimed at reducing cardiovascular disparities and thereby enhance research opportunities enrich cultural sensitivity and improve cardiovascular research capabilities at both institutions
The Request for Applications for Partnership Programs to Reduce Cardiovascular Disparities was released in September 2003 The awards were made in September 2004
DESIGN NARRATIVE
Over the past decade there has been an explosive increase in obesity among all age groups within the US population This epidemic is particularly problematic among African Americans in the Southeast Although genetic factors play a contributory role it is postulated that ethnic disparities in obesity and obesity-related CVD are related to a dynamic interplay between biological factors and the behavioral response to the unique environmental context within ethnic communities Obesity is often associated with perturbations in the metabolic and physiologic milieu A cluster of obesity-related abnormalities has been defined as the Metabolic Syndrome The CVD complications of obesity appears to be related to the capacity for adipose tissue itself to generate adipokines that directly predispose to insulin-resistance endothelial dysfunction inflammation and vascular disease
The study will use state-of-the-art approaches to define potential ethnic differences in the profile of metabolic physiologic and biochemical features associated with obesity as well as the salutary responses to lifestyle modification The program uses a multi-disciplinary strategy to systematically characterize potential ethnic differences in obesity-related CVD by drawing upon the fields of psychology physiology biochemistry nursing and clinical medicine In a thematic series of inter-related studies the programs research plan ranges from epidemiology studies within the ethnic communities to patient-centered clinical trial interventions within ethnic community practices to the analysis of novel biomarkers of human pathobiology This collaborative multi-investigator team is built upon a complementary partnership between the Morehouse School of Medicine and Emory University This partnership shares a joint commitment to address the striking ethnic disparities in the high-risk CVD population The specific aims are 1 to define the relative influence of psychosocialcultural factors and biological mediators as determinants of ethnic disparities in obesity and the metabolic syndrome in a population-based bi-racial cohort 2 to define the effectiveness of patient-targeted behavioral interventions to enhance the health of African American patients with the Metabolic Syndrome in the context of community-based clinical practices 3 to assess the impact of innovative lifestyle intervention strategies on conventional and novel biomarkers of vascular disease risk in African Americans and 4 to enhance the educationtraining of fellowspractitioners engaged in CVD disparities researchpractice and promote partnerships that enhance cardiovascular health within ethnic communities
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 1284 | OTHER | Other | httpsreporternihgovquickSearchU01HL079214 |
| U01HL079156 | NIH | None | None |
| U01HL079214 | NIH | None | None |