Ignite Creation Date:
2024-05-05 @ 11:41 AM
Last Modification Date:
2024-10-26 @ 9:11 AM
Study NCT ID:
NCT00101777
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2005-01-12
Brief Title:
Ventilatory Physiology in Children at Risk for Anxiety
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Ventilatory Physiology in Children at Risk for Anxiety
Status:
COMPLETED
Status Verified Date:
2005-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The importance of the proposed research project derives from a steady accumulation of research findings on the relationship between respiration and anxiety The relationship between panic disorder and abnormalities in respiration has been recognized for more than 10 years Increased sensitivity to CO2 exposure in panic disorder represents the most consistent finding supporting this relationship The current proposal follows naturally from three sets of recent research findings in the area of panic disorder First our group has recently shown that children with anxiety disorders like adults with panic disorder exhibit increased sensitivity to CO2 Second other researchers have shown that psychiatrically healthy relatives of patients with panic disorder also exhibit increased sensitvity to CO2 Finally our group has also recently shown that children of adults with panic disorder exhibit high rates of anxiety disorders particularly separation anxiety disorder the childhood anxiety disorder which exhibits the highest degree of CO2 sensitivity These three findings suggest that children of parents with panic disorder may exhibit a latent vulnerability to panic disorder manifested as increased sensitivity to CO2
A secondary feature of the proposed research project derives from a steady accumulation of research findings in basic science literature outlining the parts of the brain that mediate fear and anxiety in animals It may be possible to use insights from research on the brain basis of fear in animals to develop methods for assessing the brain basis of fear in humans Moreover work in animals notes changes in brain systems that mediate fear and anxiety across development If development If developmentally sensitive methods could be used to study fear in children it may also be possible to greatly enhance our understanding of the manner in which the relationship between brain function and fear changes as children age If similarities could be demonstrated across animals and humans in these areas new insights on potential treatments for anxiety could be more readily transferred from the laboratory to the clinic A second goal of the current proposal is to refine two neuropsychological probes that are thought to assess functional aspects of brain systems implicated in fear and anxiety across various species from rodents to humans
A secondary feature of the proposed research project derives from a steady accumulation of research findings in basic science literature outlining the parts of the brain that mediate fear and anxiety in animals It may be possible to use insights from research on the brain basis of fear in animals to develop methods for assessing the brain basis of fear in humans Moreover work in animals notes changes in brain systems that mediate fear and anxiety across development If development If developmentally sensitive methods could be used to study fear in children it may also be possible to greatly enhance our understanding of the manner in which the relationship between brain function and fear changes as children age If similarities could be demonstrated across animals and humans in these areas new insights on potential treatments for anxiety could be more readily transferred from the laboratory to the clinic A second goal of the current proposal is to refine two neuropsychological probes that are thought to assess functional aspects of brain systems implicated in fear and anxiety across various species from rodents to humans
Detailed Description:
The importance of the proposed research project derives from a steady accumulation of research findings on the relationship between respiration and anxiety The relationship between panic disorder and abnormalities in respiration has been recognized for more than 10 years Increased sensitivity to CO2 exposure in panic disorder represents the most consistent finding supporting this relationship The current proposal follows naturally from three sets of recent research findings in the area of panic disorder First our group has recently shown that children with anxiety disorders like adults with panic disorder exhibit increased sensitivity to CO2 Second other researchers have shown that psychiatrically healthy relatives of patients with panic disorder also exhibit increased sensitvity to CO2 Finally our group has also recently shown that children of adults with panic disorder exhibit high rates of anxiety disorders particularly separation anxiety disorder the childhood anxiety disorder which exhibits the highest degree of CO2 sensitivity These three findings suggest that children of parents with panic disorder may exhibit a latent vulnerability to panic disorder manifested as increased sensitivity to CO2
A secondary feature of the proposed research project derives from a steady accumulation of research findings in basic science literature outlining the parts of the brain that mediate fear and anxiety in animals It may be possible to use insights from research on the brain basis of fear in animals to develop methods for assessing the brain basis of fear in humans Moreover work in animals notes changes in brain systems that mediate fear and anxiety across development If developmentally sensitive methods could be used to study fear in children it may also be possible to greatly enhance our understanding of the manner in which the relationship between brain function and fear changes as children age If similarities could be demonstrated across animals and humans in these areas new insights on potential treatments for anxiety could be more readily transferred from the laboratory to the clinic A second goal of the current proposal is to refine two neuropsychological probes that are thought to assess functional aspects of brain systems implicated in fear and anxiety across various species from rodents to humans
A secondary feature of the proposed research project derives from a steady accumulation of research findings in basic science literature outlining the parts of the brain that mediate fear and anxiety in animals It may be possible to use insights from research on the brain basis of fear in animals to develop methods for assessing the brain basis of fear in humans Moreover work in animals notes changes in brain systems that mediate fear and anxiety across development If developmentally sensitive methods could be used to study fear in children it may also be possible to greatly enhance our understanding of the manner in which the relationship between brain function and fear changes as children age If similarities could be demonstrated across animals and humans in these areas new insights on potential treatments for anxiety could be more readily transferred from the laboratory to the clinic A second goal of the current proposal is to refine two neuropsychological probes that are thought to assess functional aspects of brain systems implicated in fear and anxiety across various species from rodents to humans
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-M-0093 | None | None | None |