Ignite Creation Date:
2024-05-05 @ 10:00 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005469
Status:
COMPLETED
Last Update Posted:
2016-05-13
First Post:
2000-05-25
Brief Title:
Maturational Changes in Cardiac Structures -- Blood Pressure Relationship -- SCOR in Hypertension
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2000-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To examine a school-based population of children for maturational changes in blood pressure and cardiac structures
Detailed Description:
BACKGROUND
Although excessive left ventricular mass has been viewed as an adaptation to increased blood pressure it can precede the rise in blood pressure in hypertensive models Excessive growth of the heart may reflect additional factors contributing to eventual level of blood pressure In children rapid heart growth may be predictive of subsequent high childhood blood pressure level and greater incidence of cardiovascular disease in adult relatives These studies had the potential of defining maturational changes in known risk factors which might help predict future hypertensive disease
The study was a subproject within a Specialized Center of Research SCOR in Hypertension The Request for Applications for the SCOR was released in October 1988
DESIGN NARRATIVE
A total of 124 prepubertal males and females were followed longitudinally for five years Yearly examinations defined the stages of sexual maturation On four occasions each year subjects were studied for resting and ambulatory blood pressure echocardiography anthropometry and activity assessment Once yearly each subject had blood drawn for hormone analyses and whole blood viscosity estimate From these data growth velocities of the heart and rate of change of blood pressure were determined These parameters were analyzed to determine if rapid growth of the heart preceded or followed the rise in blood pressure observed during puberty and body size and composition sexual maturation and hormone changes and sympathetic activity
The study was a subproject within a SCOR in Hypertension Approximately 7 percent of total dollars were awarded for this subproject
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Although excessive left ventricular mass has been viewed as an adaptation to increased blood pressure it can precede the rise in blood pressure in hypertensive models Excessive growth of the heart may reflect additional factors contributing to eventual level of blood pressure In children rapid heart growth may be predictive of subsequent high childhood blood pressure level and greater incidence of cardiovascular disease in adult relatives These studies had the potential of defining maturational changes in known risk factors which might help predict future hypertensive disease
The study was a subproject within a Specialized Center of Research SCOR in Hypertension The Request for Applications for the SCOR was released in October 1988
DESIGN NARRATIVE
A total of 124 prepubertal males and females were followed longitudinally for five years Yearly examinations defined the stages of sexual maturation On four occasions each year subjects were studied for resting and ambulatory blood pressure echocardiography anthropometry and activity assessment Once yearly each subject had blood drawn for hormone analyses and whole blood viscosity estimate From these data growth velocities of the heart and rate of change of blood pressure were determined These parameters were analyzed to determine if rapid growth of the heart preceded or followed the rise in blood pressure observed during puberty and body size and composition sexual maturation and hormone changes and sympathetic activity
The study was a subproject within a SCOR in Hypertension Approximately 7 percent of total dollars were awarded for this subproject
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| P50HL044546 | NIH | None | httpsreporternihgovquickSearchP50HL044546 |