Ignite Creation Date:
2024-05-05 @ 10:00 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005890
Status:
COMPLETED
Last Update Posted:
2005-06-24
First Post:
2000-06-02
Brief Title:
Diagnostic Study of Adrenal Cortical Function in Children With Septic Shock
Sponsor:
National Center for Research Resources NCRR
Organization:
National Center for Research Resources NCRR
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2003-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
OBJECTIVES
I Examine adrenal cortical function and the incidence of adrenal dysfunction in children with septic shock
II Examine the mortality length of stay in the PICU and incidence of multiorgan failure in children with adrenal dysfunction and septic shock
I Examine adrenal cortical function and the incidence of adrenal dysfunction in children with septic shock
II Examine the mortality length of stay in the PICU and incidence of multiorgan failure in children with adrenal dysfunction and septic shock
Detailed Description:
PROTOCOL OUTLINE
Patients undergo a corticotropin stimulation test within 8 hours of admission to the PICU Blood samples for plasma cortisol and corticotropin levels are drawn at time 0 followed by corticotropin 1-24 IV Additional cortisol levels are drawn at 30 and 60 minutes Corticotropin is measured by immunoradiometric assay and cortisol is measured by radioimmunoassay Mean arterial blood pressure heart rate and respiratory rate are recorded at baseline and at 60 minutes
Patients receive routine management for septic shock and multiple organ system failure
Patients undergo a corticotropin stimulation test within 8 hours of admission to the PICU Blood samples for plasma cortisol and corticotropin levels are drawn at time 0 followed by corticotropin 1-24 IV Additional cortisol levels are drawn at 30 and 60 minutes Corticotropin is measured by immunoradiometric assay and cortisol is measured by radioimmunoassay Mean arterial blood pressure heart rate and respiratory rate are recorded at baseline and at 60 minutes
Patients receive routine management for septic shock and multiple organ system failure
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| CHMC-C-96-3-5 | None | None | None |