Ignite Creation Date:
2025-12-25 @ 3:29 AM
Ignite Modification Date:
2025-12-26 @ 2:10 AM
Study NCT ID:
NCT00497705
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2007-07-06
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Genes Causing Ebstein's Anomaly
Sponsor:
National Heart, Lung, and Blood Institute (NHLBI)
Organization:
Study Overview
Official Title:
Genes Causing Congenital Ebstein's Anomaly
Status:
COMPLETED
Status Verified Date:
2009-07-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will investigate Ebstein's anomaly, a congenital abnormality of the tricuspid valve of the heart and try to identify the genetic origins of the disease.
Adults and children 2 years of age and older with Ebstein's anomaly and healthy volunteers may be eligible for this study. Participants undergo the following procedures:
* Blood tests: Three tube of blood will be collected, with the total amount limited to about half a teaspon for each two pounds of body weight.
* Saliva sample collection: A small amount of saliva is collected by spitting into a sterile container.
* Oral (cheek) swab: Cells are collected from the mouth using a soft brush to swab the inside lining of the cheek.
* Electrocardiogram: The electrical activity of the heart is recorded using electrodes placed on the chest.
* Echocardiogram: Heart function is assessed using ultrasound.
Adults and children 2 years of age and older with Ebstein's anomaly and healthy volunteers may be eligible for this study. Participants undergo the following procedures:
* Blood tests: Three tube of blood will be collected, with the total amount limited to about half a teaspon for each two pounds of body weight.
* Saliva sample collection: A small amount of saliva is collected by spitting into a sterile container.
* Oral (cheek) swab: Cells are collected from the mouth using a soft brush to swab the inside lining of the cheek.
* Electrocardiogram: The electrical activity of the heart is recorded using electrodes placed on the chest.
* Echocardiogram: Heart function is assessed using ultrasound.
Detailed Description:
The goal of this study is to elucidate the genetic basis for the congenital heart disease (CHD) known as Ebstein's anomaly. These studies complement ongoing research studies using mouse models to recover mutations causing structural heart defects associated with human CHD. By elucidating the underlying genetic causes for Ebstien's anomaly, it may be possible to improve risk assessments as well as facilitate the development of new strategies for prevention and disease management. These studies are important for early diagnosis and the management of complications associated with surviving adults with Ebstein's anomaly, some of whom have undergone surgical correction and others that are unoperated.
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary ID Infos
| Secondary ID | Type | Domain | Link | View |
|---|---|---|---|---|
| 07-H-0186 | None | None | View |