Ignite Creation Date:
2025-12-25 @ 3:30 AM
Ignite Modification Date:
2025-12-26 @ 2:11 AM
Study NCT ID:
NCT01849705
Status:
COMPLETED
Last Update Posted:
2013-05-08
First Post:
2013-05-06
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Melanocortin 4 Receptor Mutations and Obesity-associated Diseases
Sponsor:
University of Copenhagen
Organization:
Study Overview
Official Title:
Mutations in the Melanocortin 4 Receptor and Obesity-associated Diseases
Status:
COMPLETED
Status Verified Date:
2013-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Mc4Obes
Brief Summary:
Mutations in the melanocortin 4 receptor (MC4R) are the most common form of monogenic obesity, and can explain 2-6% of severe obesity.
Studies have shown that mutations in MC4R are associated with increased fat mass, height-for-age, appetite and insulin resistance among children. In adults, mutations in MC4R are less penetrant for these phenotypes but it has been observed that individuals with MC4R mutations have a smaller than expected blood pressure for their degree of obesity.
The purpose of this study is to explore the association between functional MC4R mutations and obesity, insulin resistance and blood pressure.
Studies have shown that mutations in MC4R are associated with increased fat mass, height-for-age, appetite and insulin resistance among children. In adults, mutations in MC4R are less penetrant for these phenotypes but it has been observed that individuals with MC4R mutations have a smaller than expected blood pressure for their degree of obesity.
The purpose of this study is to explore the association between functional MC4R mutations and obesity, insulin resistance and blood pressure.
Detailed Description:
None
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
Secondary ID Infos
| Secondary ID | Type | Domain | Link | View |
|---|---|---|---|---|
| H-2-1012-108 | REGISTRY | The Danish National Committee on Biomedical Research Ethics | View |