Ignite Creation Date:
2024-05-05 @ 11:43 AM
Last Modification Date:
2024-10-26 @ 9:12 AM
Study NCT ID:
NCT00118560
Status:
COMPLETED
Last Update Posted:
2011-03-17
First Post:
2005-06-30
Brief Title:
Exercise Training for Patients With Poor Leg Circulation
Sponsor:
US Department of Veterans Affairs
Organization:
VA Office of Research and Development
Study Overview
Official Title:
Perfusion and Metabolism During Exercise in Peripheral Arterial Disease
Status:
COMPLETED
Status Verified Date:
2011-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purposes of this pilot project are to a determine changes in calf muscle blood flow and energy supply resulting from calf muscle exercise and b to determine changes in these variables resulting from exercise training walking and calf muscle exercise This is a pilot study to prepare for a larger project in the future Exercise and exercise training should increase blood flow and energy supply to the calf muscles
Detailed Description:
Specific Objectives 1Develop an appropriate graded calf exercise test protocol for evaluating perfusion and metabolism during exercise in subjects with peripheral arterial disease PAD 2compare perfusion in gastroc-soleus and tibialis anterior muscles during exercise and recovery from exercise and to compare metabolism in those muscles during exercise 3compare the perfusion during exercise and recovery between groups with and without PAD and to compare metabolism during exercise between groups with and without PAD 4estimate sample sizes and effect sizes for a future clinical trial to determine the efficacy of walking and calf muscle exercise training for improving calf muscle perfusion and metabolism 5determine the sensitivity and specificity of the PET exercise test in classifying subjects into groups with or without PAD and 6 determine the test-retest reliability coefficients of perfusion and metabolic measures
Two groups of subjects will participate in this study Group I n25 subjects with PAD will undergo two sets of assessments Each assessment will consist of completing three questionnaires two exercise tests and one PET scan session Additionally they will receive one MRI of the legs Then they will participate in a three-month exercise training intervention consisting of treadmill walking and calf muscle exercise Finally they will repeat one set of assessments listed above with MRI Group II n25 healthy control subjects will undergo two sets of assessments Each assessment will consist of three questionnaires two submaximal exercise tests one MRI and one PET scan session no exercise tests Additionally they will receive only one MRI They will not participate in an exercise training intervention
Experimental Design The project is a pilot study that is both cross-sectional and longitudinal in nature The initial baseline measurement sessions will allow comparisons of acute perfusion and metabolic physiologic responses between two groups of subjects with and without PAD Duplicate testing for each subject will allow assessment of the test-retest reliability of the measurements The PAD subjects perfusion and metabolic responses will be assessed again after three months of exercise training walking and calf muscle exercise While not a definitive clinical trial of the exercise training intervention the results should provide estimates of sample and effect sizes to design a more definitive future clinical trial
Subjects Recruitment and Sampling Fifty different subjects N50 will participate in the project reflecting the available veteran patient population The sample will include primarily men of any age and ethnicity Twenty-five subjects will have PAD and will be identified and recruited via convenience sampling primarily from the Physical Medicine and Rehabilitation PMR Outpatient Clinic Diabetes Clinic and Peripheral Vascular Clinic at the VA West Los Angeles Healthcare Center VAWLAHC Other participants may be recruited from other VA Greater Los Angeles Healthcare System locations specifically the Los Angeles Ambulatory Care Center and the Sepulveda Ambulatory Care Center Twenty-five normal healthy control subjects will be recruited via convenience sampling from well veterans and the general community the two groups will be matched on gender and age We plan to enroll 25 subjects with PAD for the three-month exercise training intervention
Screening and Consent Research staff will recruit and interview prospective subjects Prospective subjects who meet all initial inclusion and exclusion criteria will be requested to review and sign the IRB-approved informed consent form and will be enrolled in the project A physician will physically examine prospective subjects and provide medical clearance prior to participation
Assessments and Measurements
After screening and consent the assessment process will progress in four phases
1 Questionnaires to evaluate walking impairment physical activity and general health The information will be used to better characterize the study groups
2 Exercise tolerance testing to demonstrate claudication symptoms in PAD subjects during both treadmill walking and calf muscle exercise and to assess functional changes resulting from training The control subjects will also perform the exercise tests but these tests will be submaximal and without pain The data will be used for comparison to the data from PAD subjects
3 Magnetic Resonance Imaging MRI of the legs to measure popliteal artery diameter and document locations of individual muscles and muscle groups
4 PET-exercise testing to measure muscle perfusion and glucose metabolism during calf muscle exercise and recovery
Two groups of subjects will participate in this study Group I n25 subjects with PAD will undergo two sets of assessments Each assessment will consist of completing three questionnaires two exercise tests and one PET scan session Additionally they will receive one MRI of the legs Then they will participate in a three-month exercise training intervention consisting of treadmill walking and calf muscle exercise Finally they will repeat one set of assessments listed above with MRI Group II n25 healthy control subjects will undergo two sets of assessments Each assessment will consist of three questionnaires two submaximal exercise tests one MRI and one PET scan session no exercise tests Additionally they will receive only one MRI They will not participate in an exercise training intervention
Experimental Design The project is a pilot study that is both cross-sectional and longitudinal in nature The initial baseline measurement sessions will allow comparisons of acute perfusion and metabolic physiologic responses between two groups of subjects with and without PAD Duplicate testing for each subject will allow assessment of the test-retest reliability of the measurements The PAD subjects perfusion and metabolic responses will be assessed again after three months of exercise training walking and calf muscle exercise While not a definitive clinical trial of the exercise training intervention the results should provide estimates of sample and effect sizes to design a more definitive future clinical trial
Subjects Recruitment and Sampling Fifty different subjects N50 will participate in the project reflecting the available veteran patient population The sample will include primarily men of any age and ethnicity Twenty-five subjects will have PAD and will be identified and recruited via convenience sampling primarily from the Physical Medicine and Rehabilitation PMR Outpatient Clinic Diabetes Clinic and Peripheral Vascular Clinic at the VA West Los Angeles Healthcare Center VAWLAHC Other participants may be recruited from other VA Greater Los Angeles Healthcare System locations specifically the Los Angeles Ambulatory Care Center and the Sepulveda Ambulatory Care Center Twenty-five normal healthy control subjects will be recruited via convenience sampling from well veterans and the general community the two groups will be matched on gender and age We plan to enroll 25 subjects with PAD for the three-month exercise training intervention
Screening and Consent Research staff will recruit and interview prospective subjects Prospective subjects who meet all initial inclusion and exclusion criteria will be requested to review and sign the IRB-approved informed consent form and will be enrolled in the project A physician will physically examine prospective subjects and provide medical clearance prior to participation
Assessments and Measurements
After screening and consent the assessment process will progress in four phases
1 Questionnaires to evaluate walking impairment physical activity and general health The information will be used to better characterize the study groups
2 Exercise tolerance testing to demonstrate claudication symptoms in PAD subjects during both treadmill walking and calf muscle exercise and to assess functional changes resulting from training The control subjects will also perform the exercise tests but these tests will be submaximal and without pain The data will be used for comparison to the data from PAD subjects
3 Magnetic Resonance Imaging MRI of the legs to measure popliteal artery diameter and document locations of individual muscles and muscle groups
4 PET-exercise testing to measure muscle perfusion and glucose metabolism during calf muscle exercise and recovery
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None