Ignite Creation Date:
2024-05-06 @ 1:02 AM
Last Modification Date:
2024-10-26 @ 10:58 AM
Study NCT ID:
NCT01717846
Status:
WITHDRAWN
Last Update Posted:
2016-05-11
First Post:
2012-10-24
Brief Title:
Effect on Orencia Abatacept on the Apoptosis of T Cells B Cells and APC Cells in Rheumatoid Arthritis
Sponsor:
University of California Los Angeles
Organization:
University of California Los Angeles
Study Overview
Official Title:
In Vivo Effect on Orencia Abatacept on the Apoptosis of T Cells B Cells and Antigen Presenting APC Cells in Rheumatoid Arthritis
Status:
WITHDRAWN
Status Verified Date:
2016-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
The PI has left UCLA and we do not plan to pursue this study
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
RA
Brief Summary:
This proposal will test the hypothesis that Orencia affects apoptosis and apoptosis related genesbiomarkers in vivo in rheumatoid arthritis RA patients
Detailed Description:
Orencia may regulate apoptosis and apoptosis related genes in vivo in rheumatoid arthritis RA patients cells To date no studies have been performed to evaluate the effect of Orencia on apoptosis in RA patients
Primary To determine the effect of Abatacept in the apoptosis of T cells B cells and antigen presenting cells APC in RA patients at baseline 3 months and 6 months
Secondary To evaluate the association between the changes in apoptosis to changes in disease activity measures DAS28ESR over 6 months of treatment with subcutaneous injection of abatacept
Primary To determine the effect of Abatacept in the apoptosis of T cells B cells and antigen presenting cells APC in RA patients at baseline 3 months and 6 months
Secondary To evaluate the association between the changes in apoptosis to changes in disease activity measures DAS28ESR over 6 months of treatment with subcutaneous injection of abatacept
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| IM101-356 | OTHER | BMS | None |