Ignite Creation Date:
2024-05-05 @ 11:44 AM
Last Modification Date:
2024-10-26 @ 9:12 AM
Study NCT ID:
NCT00115752
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2005-06-23
Brief Title:
Genetic Basis For Variation In NSAID Analgesia In A Clinical Model Of Acute Pain
Sponsor:
National Institute of Nursing Research NINR
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Genetic Basis For Variation In NSAID Analgesia In A Clinical Model Of Acute Pain
Status:
COMPLETED
Status Verified Date:
2006-10-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will evaluate how genetic makeup contributes to the variation in people regarding their sensitivity to and experience of pain Scientists believe that differences in information found in genes may explain why an analgesic drug that is one that treats pain works effectively for some people but not for others The study will explore pain that is acute fast and short period Knowledge gained from this ongoing study may permit development of an individualized analgesic drug prescription
Patients ages 16 to 35 who are in good health and have been referred for removal of impacted wisdom teeth who are not allergic to aspirin or other nonsteroidal anti-inflammatory drugs known as NSAIDs sulfites or certain anesthetics who are not pregnant or nursing and who are willing to have a biopsy before and after dental surgery are eligible for this study
Patients will come to the clinic for one test visit and one treatment visit During the first visit a questionnaire will evaluate patients psychological state including mood and depression There will be a clinical examination of their wisdom teeth A blood sample of 10 milliliters about 04 ounces will be collected from the forearm to provide DNA material containing genes stored in cells The primary genetic analysis will be done at NIH although the DNA collected might also be sent to a laboratory outside NIH DNA samples will be coded so that names of patients cannot be traced
During the second visit two of the patients lower wisdom teeth will be removed Patients will be given a local anesthetic in the mouth and a sedative given through a vein in the arm While the mouth is numb a small piece of tissue will be removed from inside the cheek near the wisdom tooth It is the first biopsy After the two wisdom teeth are removed a small piece of tubing will be placed into both sides of the mouth where the teeth were removed Every 20 minutes for the next 3 hours the researchers will collect inflammatory fluid from the tubing to measure the chemicals thought to cause pain and swelling Also every 20 minutes patients will rate the pain they feel by answering questions If there is pain before 3 hours following surgery they will receive a dose of fentanyl to relieve moderate to severe pain A second biopsy will occur 3 hours after surgery to measure changes in chemicals produced in response to surgery Immediately afterward patients will receive 30 mg of ketorolac Toradol whether or not pain is felt They will answer questionnaires about pain for 3 hours after receiving the drug to rate how well it works They will stay at the clinic up to 6 hours after the surgery If pain is not relieved with ketorolac patients will receive a one-time dose of tramadol a pain medication for moderate to severe pain After the study procedures are completed patients will receive pain medication for pain after surgery
Patients will be monitored closely because all drugs have side effects Ketorolac is a nonsteroidal anti-inflammatory drug one that may cause gastrointestinal upset Fentanyl is a powerful narcotic drug that is safe at the dosage used in this study but stomach upset dizziness and breathing trouble may occur Also risks from the biopsy include discomfort from injecting the numbing medicine infection and bleeding There may be discomfort from the sedative injected into the vein and there may be bruising
Benefits from participating are having wisdom teeth removed at no cost as well as close monitoring before and after surgery There are no plans to give patients the results of genetic tests or questionnaires Years of research may be needed before such information has the chance to become meaningful
Patients ages 16 to 35 who are in good health and have been referred for removal of impacted wisdom teeth who are not allergic to aspirin or other nonsteroidal anti-inflammatory drugs known as NSAIDs sulfites or certain anesthetics who are not pregnant or nursing and who are willing to have a biopsy before and after dental surgery are eligible for this study
Patients will come to the clinic for one test visit and one treatment visit During the first visit a questionnaire will evaluate patients psychological state including mood and depression There will be a clinical examination of their wisdom teeth A blood sample of 10 milliliters about 04 ounces will be collected from the forearm to provide DNA material containing genes stored in cells The primary genetic analysis will be done at NIH although the DNA collected might also be sent to a laboratory outside NIH DNA samples will be coded so that names of patients cannot be traced
During the second visit two of the patients lower wisdom teeth will be removed Patients will be given a local anesthetic in the mouth and a sedative given through a vein in the arm While the mouth is numb a small piece of tissue will be removed from inside the cheek near the wisdom tooth It is the first biopsy After the two wisdom teeth are removed a small piece of tubing will be placed into both sides of the mouth where the teeth were removed Every 20 minutes for the next 3 hours the researchers will collect inflammatory fluid from the tubing to measure the chemicals thought to cause pain and swelling Also every 20 minutes patients will rate the pain they feel by answering questions If there is pain before 3 hours following surgery they will receive a dose of fentanyl to relieve moderate to severe pain A second biopsy will occur 3 hours after surgery to measure changes in chemicals produced in response to surgery Immediately afterward patients will receive 30 mg of ketorolac Toradol whether or not pain is felt They will answer questionnaires about pain for 3 hours after receiving the drug to rate how well it works They will stay at the clinic up to 6 hours after the surgery If pain is not relieved with ketorolac patients will receive a one-time dose of tramadol a pain medication for moderate to severe pain After the study procedures are completed patients will receive pain medication for pain after surgery
Patients will be monitored closely because all drugs have side effects Ketorolac is a nonsteroidal anti-inflammatory drug one that may cause gastrointestinal upset Fentanyl is a powerful narcotic drug that is safe at the dosage used in this study but stomach upset dizziness and breathing trouble may occur Also risks from the biopsy include discomfort from injecting the numbing medicine infection and bleeding There may be discomfort from the sedative injected into the vein and there may be bruising
Benefits from participating are having wisdom teeth removed at no cost as well as close monitoring before and after surgery There are no plans to give patients the results of genetic tests or questionnaires Years of research may be needed before such information has the chance to become meaningful
Detailed Description:
The proposed clinical trial will evaluate the role of genetic factors including single nucleotide polymorphisms from cyclooxygenase COX - 2 gene on acute pain after tissue injury and the analgesic effect of a COX inhibitor Patients will be healthy volunteers scheduled for the surgical removal of impacted third molars Genotyping will be performed before surgery and patients stratified to treatment with a COX inhibitor in this protocol or to other protocols examining different polymorphisms
Under local anesthesia 2 mandibular third molars will be removed Microdialysis sampling in the extraction socket will be performed with pre- and post-surgical biopsies Patients will receive a COX inhibitor as an analgesic drug for the post-operative pain Outcomes evaluated will include clinical pain response gene expression profile using microarray and quantitation of related proteins after oral surgery and the interaction of these factors with analgesia by a COX inhibitor By studying these responses in patient samples for each genotype non-variant homozygote heterozygote and variant homozygote from the COX-2 gene we will attempt to replicate and extend previous findings on the role of genetic factors in the inflammatory process clinical pain and variation in response to analgesic drugs
Under local anesthesia 2 mandibular third molars will be removed Microdialysis sampling in the extraction socket will be performed with pre- and post-surgical biopsies Patients will receive a COX inhibitor as an analgesic drug for the post-operative pain Outcomes evaluated will include clinical pain response gene expression profile using microarray and quantitation of related proteins after oral surgery and the interaction of these factors with analgesia by a COX inhibitor By studying these responses in patient samples for each genotype non-variant homozygote heterozygote and variant homozygote from the COX-2 gene we will attempt to replicate and extend previous findings on the role of genetic factors in the inflammatory process clinical pain and variation in response to analgesic drugs
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 05-NR-0176 | None | None | None |