Ignite Creation Date:
2024-05-05 @ 10:01 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001742
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
The Role of Cyclooxygenase Activity in the Endothelial Function of Hypertensive and Hypercholesterolemic Patients
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
The Role of Cyclooxygenase Activity in the Endothelial Function of Hypertensive and Hypercholesterolemic Patients
Status:
COMPLETED
Status Verified Date:
2000-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
A layer of cells called the endothelium line the walls of blood vessels These cells produce substances that control the tone of blood vessels and thus control blood flow through the vessel This regulating activity of the endothelium is dysfunctional in several diseases of the heart and blood vessels including high blood pressure and high levels of cholesterol
Previous research has pointed toward a decrease in the action of nitric oxide NO as the cause of this abnormality Nitric oxide is a substance produced by the cells of the endothelium that plays a role in the relaxation of blood vessels
In this project researchers plan to study blood flow through the blood vessels in patients forearms after receiving four different drugs sodium nitroprusside acetylcholine L-NMMA and aspirin These four drugs act on the blood vessels of the forearm through different mechanisms Acetylcholine and sodium nitroprusside are drugs that open the blood vessels of the forearm and increase blood flow through the vessel L-NMMA is a drug that blocks production of nitric oxide NO Aspirins role in controlling blood flow is unknown
Patients participating in this research study will not directly benefit from it However the study will contribute to researchers understanding of diseases of the blood vessels and heart
Previous research has pointed toward a decrease in the action of nitric oxide NO as the cause of this abnormality Nitric oxide is a substance produced by the cells of the endothelium that plays a role in the relaxation of blood vessels
In this project researchers plan to study blood flow through the blood vessels in patients forearms after receiving four different drugs sodium nitroprusside acetylcholine L-NMMA and aspirin These four drugs act on the blood vessels of the forearm through different mechanisms Acetylcholine and sodium nitroprusside are drugs that open the blood vessels of the forearm and increase blood flow through the vessel L-NMMA is a drug that blocks production of nitric oxide NO Aspirins role in controlling blood flow is unknown
Patients participating in this research study will not directly benefit from it However the study will contribute to researchers understanding of diseases of the blood vessels and heart
Detailed Description:
The endothelium modulates vascular tone by the release of constricting and relaxing substances that act on the underlying smooth muscle This regulatory activity of the endothelium is dysfunctional in a number of cardiovascular conditions including essential hypertension and hypercholesterolemia Previous studies from our group have implicated a decreased action of endothelium-derived nitric oxide NO as the mechanism responsible for this abnormality Whether this reduced bioactivity of NO is related to vasoactive prostanoids remains uncertain
We propose to test the hypothesis that an increased production of vasoactive prostanoids by the cyclooxygenase COX system is responsible for the reduced bioactivity of NO in essential hypertension and hypercholesterolemia We will investigate the effect of COX inhibition by aspirin ASA on resting vascular tone and on both endothelium-dependent and independent vasodilation in normal subjects hypertensive patients and hypercholesterolemic patients
For this purpose we propose to analyze the regional vascular responses to acetylcholine ACH and to sodium nitroprusside SNP before and after the administration of ASA We will also analyze the basal forearm blood flow FBF responses to increasing doses of ASA infusion We will employ infusion of drugs into the brachial artery and we will measure the responses of the forearm vasculature by means of strain gauge plethysmography
We propose to test the hypothesis that an increased production of vasoactive prostanoids by the cyclooxygenase COX system is responsible for the reduced bioactivity of NO in essential hypertension and hypercholesterolemia We will investigate the effect of COX inhibition by aspirin ASA on resting vascular tone and on both endothelium-dependent and independent vasodilation in normal subjects hypertensive patients and hypercholesterolemic patients
For this purpose we propose to analyze the regional vascular responses to acetylcholine ACH and to sodium nitroprusside SNP before and after the administration of ASA We will also analyze the basal forearm blood flow FBF responses to increasing doses of ASA infusion We will employ infusion of drugs into the brachial artery and we will measure the responses of the forearm vasculature by means of strain gauge plethysmography
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 98-H-0064 | None | None | None |