Ignite Creation Date:
2024-05-05 @ 11:45 AM
Last Modification Date:
2024-10-26 @ 9:12 AM
Study NCT ID:
NCT00120731
Status:
WITHDRAWN
Last Update Posted:
2020-11-05
First Post:
2005-07-12
Brief Title:
Effects of Potassium Citrate in Urine of Children With Elevated Calcium in Urine and Kidney Stones
Sponsor:
Childrens Mercy Hospital Kansas City
Organization:
Childrens Mercy Hospital Kansas City
Study Overview
Official Title:
Urinary Chemistry and Acid-Base Effects of Potassium Citrate in Children With Idiopathic Hypercalciuria and Urolithiasis
Status:
WITHDRAWN
Status Verified Date:
2020-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Determined not feasible
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
High amounts of calcium in the urine hypercalciuria can cause development of kidney stones in children Treatment for these children includes plenty of fluids a low-salt diet and medications such as potassium citrate A major advantage of potassium citrate as compared to hydrochlorothiazide is its lack of side effects One problem the researchers and others have observed is that some children continue to form kidney stones despite correction of hypercalciuria with potassium citrate One possible explanation is that in some individuals potassium citrate therapy results in an excessive elevation of urine pH a situation that may predispose to calcium phosphate stone formation In this study the researchers will study the effects of potassium citrate on urine chemistries and acid-base balance in three groups of children aged 5-17 years
children who are hypercalciuric stone formers
healthy children without a history of hypercalciuria or kidney stones
Particular attention will be paid to try to identify those who develop a very high urine pH 8 and the factors leading to this metabolic reaction
The researchers will try to learn whether it is the childs characteristics the disease manifestations the dose of the drug or a combination of the above which may be the cause of the development of very alkaline urine Based on the results the researchers hope to be able to better tailor the individual treatment for each child with kidney stones
children who are hypercalciuric stone formers
healthy children without a history of hypercalciuria or kidney stones
Particular attention will be paid to try to identify those who develop a very high urine pH 8 and the factors leading to this metabolic reaction
The researchers will try to learn whether it is the childs characteristics the disease manifestations the dose of the drug or a combination of the above which may be the cause of the development of very alkaline urine Based on the results the researchers hope to be able to better tailor the individual treatment for each child with kidney stones
Detailed Description:
Hypercalciuria is a common clinical pediatric problem that in some children is associated with renal stones Most renal stones 80 are formed by calcium oxalate calcium phosphate phases apatite and brushite calcium monohydrogen phosphate Hypercalciuria can be either primary accounts for the vast majority of children with calcium stones or secondary Treatment for children with calcium stones involves non-pharmacological and pharmacological interventions Non-pharmacological interventions include high fluid intake low sodium and potassium enhanced diet with RDA calcium and protein Historically the specific treatment for hypercalciuric stone formers has included thiazides which reduce calciuria lower the urinary saturation of calcium oxalate and phosphate and restore normal intestinal calcium absorption However thiazides induce hypokalemia and hypocitraturia and the latter attenuates the beneficial effects of the drug on stone formation Currently the drug of choice replacing thiazides in treating idiopathic hypercalciuria is potassium citrate Potassium citrate is readily absorbed from the gastrointestinal tract and after being excreted in the urine it inhibits the crystallization of stone forming calcium salts by binding the calcium ion thus decreasing its urinary saturation and inhibiting the nucleation and crystal growth of calcium oxalate therefore potassium citrate is an effective stone inhibitor agent A major advantage of potassium citrate is its lack of side effects One of the problems seen in clinical practice is that some children with primary hypercalciuria even after the calciuria is treated successfully with potassium citrate continue to develop stones It has been suggested that an elevation in urine pH seen in some patients treated with potassium citrate may result in an alkaline urinary milieu which promotes calcium phosphate stone formation In this study the researchers plan to investigate the effects of potassium citrate on urine chemistries and acid-base balance in children who are hypercalciuric stone formers The researchers will try to identify whether the beneficial effects of potassium citrate supplementation on lowering urine calcium and increasing citrate might be offset by too high urine pH 8 which could promote the formation of calcium phosphate stones Three groups of subjects aged 5-17 years will be studied group 1 - idiopathic hypercalciuric stone formers group 2 - idiopathic hypercalciuric non-stone formers and group 3 - normocalciuric subjects Three visits will be scheduled for each participant and the subjects will receive two doses of potassium citrate Urine chemistries and acid-base parameters will be measured The researchers will try to learn whether it is the childs characteristics the disease manifestations the dose of the drug or a combination of the above which may be the cause of the development of very alkaline urine Based on the study results the researchers hope to be able to better tailor the individual treatment for each child with kidney stones due to idiopathic hypercalciuria
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None