Ignite Creation Date:
2024-05-05 @ 11:48 AM
Last Modification Date:
2024-10-26 @ 9:13 AM
Study NCT ID:
NCT00137774
Status:
COMPLETED
Last Update Posted:
2013-04-09
First Post:
2005-08-26
Brief Title:
Bevacizumab in Combination With Temozolomide in Patients With Neuroendocrine Tumors
Sponsor:
Dana-Farber Cancer Institute
Organization:
Dana-Farber Cancer Institute
Study Overview
Official Title:
A Phase II Study of Bevacizumab in Combination With Temozolomide in Patients With Advanced Neuroendocrine Tumors
Status:
COMPLETED
Status Verified Date:
2013-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine what effects good and bad bevacizumab and temozolomide have on patients with neuroendocrine tumors
Detailed Description:
Patients will receive temozolomide orally once daily for one week followed by a one-week rest period This one-week onone week off schedule will continue for the duration of treatment unless significant side effects develop
Bevacizumab will be administered intravenously every other week After eight weeks two cycles a CT scan will be performed to see how treatment affected tumor growth
Bactrim an antibiotic and acyclovir an antiviral medicine will be given in order to help prevent infection
Blood tests will be done every other week to evaluate any side effects
Once the study has been completed a physical exam vital signs blood tests and CT scan will be performed
Patients will remain on the study as long as they continue to receive benefit from the treatment and there are no serious side effects
Bevacizumab will be administered intravenously every other week After eight weeks two cycles a CT scan will be performed to see how treatment affected tumor growth
Bactrim an antibiotic and acyclovir an antiviral medicine will be given in order to help prevent infection
Blood tests will be done every other week to evaluate any side effects
Once the study has been completed a physical exam vital signs blood tests and CT scan will be performed
Patients will remain on the study as long as they continue to receive benefit from the treatment and there are no serious side effects
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None