Ignite Creation Date:
2024-05-06 @ 1:40 AM
Last Modification Date:
2024-10-26 @ 11:08 AM
Study NCT ID:
NCT01877291
Status:
COMPLETED
Last Update Posted:
2013-06-17
First Post:
2013-06-11
Brief Title:
Young Smokers Have Impaired Airway Defense
Sponsor:
University of Sao Paulo
Organization:
University of Sao Paulo
Study Overview
Official Title:
Young Smokers Have Impaired Airway Defense That is Not Associated With Pulmonary Function
Status:
COMPLETED
Status Verified Date:
2013-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Background Smoking is a key factor for development and progression of chronic obstructive pulmonary disease COPD Although persons with COPD often have concomitant nasal disease there are few studies that report physiological or inflammatory changes in the upper airways in young asymptomatic smokers The investigators investigated physiologic and inflammatory changes in the nasal and lower airways of young smokers and if these changes were related to smoking history
Methods Seventy-two subjects aged 35 years 32 healthy nonsmokers and 40 young smokers participated in this study The investigators measured nasal mucociliary clearance MCC nasal mucus physical properties cell count myeloperoxidase and cytokines concentrations in nasal lavage fluid exhaled breath condensate EBC pH and lung function
Methods Seventy-two subjects aged 35 years 32 healthy nonsmokers and 40 young smokers participated in this study The investigators measured nasal mucociliary clearance MCC nasal mucus physical properties cell count myeloperoxidase and cytokines concentrations in nasal lavage fluid exhaled breath condensate EBC pH and lung function
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None