Ignite Creation Date:
2024-05-06 @ 1:41 AM
Last Modification Date:
2024-10-26 @ 11:08 AM
Study NCT ID:
NCT01871883
Status:
UNKNOWN
Last Update Posted:
2015-12-02
First Post:
2013-05-27
Brief Title:
TRPV Expression in Subjects With Sensitive Skin
Sponsor:
Universidad Autonoma de San Luis Potosí
Organization:
Universidad Autonoma de San Luis Potosí
Study Overview
Official Title:
Distribution and Expression of Non-neuronal Transient Receptor Potential TRPV Ion Channels in Sensitive Skin Syndrome
Status:
UNKNOWN
Status Verified Date:
2015-11
Last Known Status:
ENROLLING_BY_INVITATION
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Sensitive skin syndrome is defined as the presence of burning itching or any other unpleasant sensation on the skin due to physical chemical or psychological factors It is frequently a self-diagnosed condition and there are no accurate tests to recognize or quantify it because of the individual variations in perception and intensity of the related symptoms The most accepted physiopathogenic theory is the presence of an altered barrier function of epidermis Also changes in the pH of the stratum corneum have been found to induce skin sensitivity through the activation of the transient potential receptor vanilloid TRPV neuronal receptors
TRPV1 has been found in human keratinocytes although its physiologic role in the skin is not yet established Their presence in keratinocytes and cutaneous nervous fibers suggests a role in the sensitive function of the epidermis Since this receptors can be activated by low pH 59 which is also important for the development of sensitive skin we hypothesized that an increase in the expression of these receptors can be the responsible for the syndrome
TRPV1 has been found in human keratinocytes although its physiologic role in the skin is not yet established Their presence in keratinocytes and cutaneous nervous fibers suggests a role in the sensitive function of the epidermis Since this receptors can be activated by low pH 59 which is also important for the development of sensitive skin we hypothesized that an increase in the expression of these receptors can be the responsible for the syndrome
Detailed Description:
Sensitive skin syndrome is defined as the presence of burning itching or any other unpleasant sensation on the skin due to physical chemical or psychological factors It is frequently a self-diagnosed condition and there are no accurate tests to recognize or quantify it because of the individual variations in perception and intensity of the related symptoms
Although the pathogenesis of sensitive skin syndrome is not completely understood the most accepted theory is the presence of an altered barrier function Irritation results from the abnormal penetration of substances to deeper layers of the skin where they can induce vasodilation and stimulate c-type neuronal fibers Also changes in the pH of the stratum corneum have been found to induce skin sensitivity through the activation of the transient potential receptor vanilloid TRPV neuronal receptors
TRPV1 was first discovered in 1997 when it was identified as the specific receptor for capsaicin in a subgroup of nociceptors It is a non-selective thermo-sensitive cationic channel that can be found in nerves from the central and peripheral nervous system fibroblasts smooth muscle mast cells endothelial cells gastrointestinal respiratory and urinary epithelial cells TRPV1 can be activated by excessive heat 42ºC acidic pH 59 and also by endogenous substances such as N- arachidonoyl dopamine leucotriene B phospholipase C and many others
In 2001 the functional expression of TRPV1 was identified in human keratinocytes Their physiologic role in the skin has not been completely understood but they have been related to differentiation proliferation inflammation and homeostasis of the epidermal barrier Their presence in keratinocytes and cutaneous nervous fibers suggests a role in the sensitive function of the epidermis It has been proved that the stimulation of TRPV1 in neuronal cells can induce pruritus and burning sensation In vitro studies have demonstrated that the exogenous stimulation of TRPV1 in keratinocytes induces the release of nitric oxide ATP dopamine prostaglandins and other pro-inflammatory substances that can act as paracrine mediators between keratinocytes and cutaneous nerve fibers Therefore there are scientific bases to hypothesize that an increase in the expression of these receptors can be the responsible for the sensitive skin syndrome
Although the pathogenesis of sensitive skin syndrome is not completely understood the most accepted theory is the presence of an altered barrier function Irritation results from the abnormal penetration of substances to deeper layers of the skin where they can induce vasodilation and stimulate c-type neuronal fibers Also changes in the pH of the stratum corneum have been found to induce skin sensitivity through the activation of the transient potential receptor vanilloid TRPV neuronal receptors
TRPV1 was first discovered in 1997 when it was identified as the specific receptor for capsaicin in a subgroup of nociceptors It is a non-selective thermo-sensitive cationic channel that can be found in nerves from the central and peripheral nervous system fibroblasts smooth muscle mast cells endothelial cells gastrointestinal respiratory and urinary epithelial cells TRPV1 can be activated by excessive heat 42ºC acidic pH 59 and also by endogenous substances such as N- arachidonoyl dopamine leucotriene B phospholipase C and many others
In 2001 the functional expression of TRPV1 was identified in human keratinocytes Their physiologic role in the skin has not been completely understood but they have been related to differentiation proliferation inflammation and homeostasis of the epidermal barrier Their presence in keratinocytes and cutaneous nervous fibers suggests a role in the sensitive function of the epidermis It has been proved that the stimulation of TRPV1 in neuronal cells can induce pruritus and burning sensation In vitro studies have demonstrated that the exogenous stimulation of TRPV1 in keratinocytes induces the release of nitric oxide ATP dopamine prostaglandins and other pro-inflammatory substances that can act as paracrine mediators between keratinocytes and cutaneous nerve fibers Therefore there are scientific bases to hypothesize that an increase in the expression of these receptors can be the responsible for the sensitive skin syndrome
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None